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XEN 445

Catalog #: 5839 Datasheet / COA / SDS

Discontinued Product

5839 has been discontinued.
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XEN 445 | CAS No. 1515856-92-4 | Lipase Inhibitors
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Description: Selective endothelial lipase inhibitor; orally bioavailable

Chemical Name: 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid

Purity: ≥98%

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Biological Activity

XEN 445 is a selective endothelial lipase (EL) inhibitor (IC50 = 237 nM for human EL). Exhibits >20-fold selectivity for EL over lipoprotein lipase (LPL) and hepatic lipase (HL). Increases high density lipoprotein cholesterol (HDLc) plasma levels in mice. Orally bioavailable.

Technical Data

M.Wt:
366.33
Formula:
C18H17F3N2O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1515856-92-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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