XEN 445

Key Product Details

Product Description

XEN 445 is a selective endothelial lipase (EL) inhibitor (IC₅₀ = 237 nM for human EL). Exhibits >20-fold selectivity for EL over lipoprotein lipase (LPL) and hepatic lipase (HL). Increases high density lipoprotein cholesterol (HDLc) plasma levels in mice. Orally bioavailable.

Product Specifications for XEN 445

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for XEN 445

The following data is based on the product molecular weight 366.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.73 mL	13.65 mL	27.30 mL
5 mM	0.55 mL	2.73 mL	5.46 mL
10 mM	0.27 mL	1.36 mL	2.73 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sun Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg.Med.Chem. 2013 PMID: 24211162

Product Documents for XEN 445