Group III mGlu receptor agonist that exhibits higher potency at mGlu4
values are 49 and 124 μ
M respectively) with no activity at mGlu7
. Selectively inhibits synaptic activity in the lateral perforant pathway (IC50
values are 130 and 1859 μ
M in the lateral and medial perforant pathways respectively). Conformationally restrained analog of L-AP4
(Cat No. 0103).
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All Tocris products are intended for laboratory research use only.
Cyclic analogues of 2-amino-4-phosphonobutanoic acid (APB) and their inhibition of hippocampal excitatory transmission and displacement of [3H]APB binding.
Crooks et al.
Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated.
Ayala et al.
Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the lateral olfactory tract-piriform cortex synpase.
Jones et al.