Z-Guggulsterone

  ( 1 citations )    
Product Datasheet
Catalog Number:3570
Chemical Name:(Z)-Pregna-4,17(20)-diene-3,16-dione
Product Details
Citations (1)
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Biological Activity
Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo. More active isomer of guggulsterone (Cat. No. 2013).
Technical Data
  • M.Wt:
    312.45
  • Formula:
    C21H28O2
  • Solubility:
    Soluble to 20 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    39025-23-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Z-Guggulsterone include:

1 Citations: Showing 1 - 1

  1. C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties.
    Authors: Ng Et al.
    Oncotarget  2016;7:24005

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