Chemical Name: 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride
Biological ActivityZatebradine hydrochloride is a bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current If (HCN channel) in sinoatrial node cells (EC50 = 480 nM) and Purkinje fibres. Displays negative chronotropic activity in isolated guinea pig atria (EC50 of 13.4 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Use- and frequency-dependent blockade by UL-FS 49 of the if pacemaker current in sheep cardiac Purkinje fibres.
Van Bogaert et al.
Use-dependent block of the pacemaker current I(f) in rabbit sinoatrial node cells by zatebradine (UL-FS 49). On the mode of action of sinus node inhibitors.
Goethals et al.
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current.
Romanelli et al.
Citation for Zatebradine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Zatebradine hydrochloride include:
1 Citation: Showing 1 - 1
Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation.
Authors: Bender Et al.
J Neurosci 2007;27:4697
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