Bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current If
(HCN channel) in sinoatrial node cells (EC50
= 480 nM) and Purkinje fibres. Displays negative chronotropic activity in isolated guinea pig atria (EC50
of 13.4 μ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Use- and frequency-dependent blockade by UL-FS 49 of the if pacemaker current in sheep cardiac Purkinje fibres.
Van Bogaert et al.
Use-dependent block of the pacemaker current I(f) in rabbit sinoatrial node cells by zatebradine (UL-FS 49). On the mode of action of sinus node inhibitors.
Goethals et al.
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current.
Romanelli et al.
The citations listed below are publications that use Tocris products. Selected citations for Zatebradine hydrochloride include:
Showing Results 1 - 1 of 1