Catalog Number: 2202
Alternate Names: UL-FS 49
Chemical Name: 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride
Biological Activity
Bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current If (HCN channel) in sinoatrial node cells (EC50 = 480 nM) and Purkinje fibres. Displays negative chronotropic activity in isolated guinea pig atria (EC50 of 13.4 μM).
Technical Data
  • M.Wt:
    493.04
  • Formula:
    C26H36N2O5.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    91940-87-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Use- and frequency-dependent blockade by UL-FS 49 of the if pacemaker current in sheep cardiac Purkinje fibres.
    Van Bogaert et al.
    Eur.J.Pharmacol., 1990;187:241
  2. Use-dependent block of the pacemaker current I(f) in rabbit sinoatrial node cells by zatebradine (UL-FS 49). On the mode of action of sinus node inhibitors.
    Goethals et al.
    Circulation, 1993;88:2389
  3. Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current.
    Romanelli et al.
    Bioorg.Med.Chem., 2005;13:1211
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Zatebradine hydrochloride include:

1 Citations: Showing 1 - 1

  1. Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation.
    Authors: Bender Et al.
    J Neurosci 2007;27:4697

Have you used Zatebradine hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information