ZD 7288

Tocris Bioscience | Catalog # 1000

Inhibits pacemaker (If) current
Tocris Bioscience

Key Product Details

Description

Inhibits pacemaker (If) current

Alternative Names

ICI D7288
View all Ion Channel Modulators »

Product Description

ZD 7288 is a sino-atrial node function modulator; blocks the hyperpolarization activated cation current If (HCN channel). Blocks Ih in central neurons. Increases NMDA-evoked noradrenaline release in rat brain in vitro.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Product Specifications for ZD 7288

Molecular Weight

292.81

Formula

C15H21ClN4

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride

CAS Number

133059-99-1

PubChem ID

123983

InChI Key

DUWKUHWHTPRMAP-UHFFFAOYSA-N

SMILES

[Cl-].CCN(C1=CC=CC=C1)C1=CC(NC)=[N+](C)C(C)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 29.28 100
DMSO 29.28 100

Preparing Stock Solutions for ZD 7288

The following data is based on the product molecular weight 292.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.08 mL 34.15 mL
5 mM 0.68 mL 3.42 mL 6.83 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 2075 publications citing the usage of this product.

Product Documents for ZD 7288

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ZD 7288

For research use only

Customer Reviews for ZD 7288 (1)

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  • test
    Name: Sergiy Sylantyev
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 12/22/2020
    No problem with dissolution in water and preparation of 10 mM stock.
    We used ZD-7288 to block Ih current in hippocampal pyramidal cells. 10 µM concentration of the compound developed its effect within a characteristic time interval of tens of seconds, making slower decay kinetics of evoked post-synaptic potentials (see illustration). Washout for 15-20 minutes could not restore the control response characteristics, thus suggesting high affinity of the compound.
    ZD 7288 1000

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