Catalog Number: 1000
Alternate Names: ICI D7288
Chemical Name: 4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride
Biological Activity
Sino-atrial node function modulator; blocks the hyperpolarization activated cation current If (HCN channel). Blocks Ih in central neurons. Increases NMDA-evoked noradrenalin release in rat brain in vitro.
Technical Data
  • M.Wt:
    292.81
  • Formula:
    C15H21ClN4
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    133059-99-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
  1. Inhibitory actions of ZENECA ZD7288 on whole cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells.
    BoSmith et al.
    Br.J.Pharmacol., 1993;110:343
  2. Ih channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices.
    Klar et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 2003;367:422
  3. Pharmacological characterization of the inwardly rectifying current in the smooth muscle cells of the rat bladder.
    Green et al.
    Br.J.Pharmacol., 1996;119:1509
  4. Mechanism of block by ZD7288 of the hyperpolarization-activated inward rectifying current in guinea-pig substantia nigra neurons in vitro.
    Harris and Constanti
    J.Neurophysiol., 1995;74:2366
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ZD 7288 include:

30 Citations: Showing 1 - 10
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  1. Electrophysiological characterization of the M-current in rat hypoglossal motoneurons
    Authors: Ghezzi? Et al.
    Neuroscience 2016;340:62
  2. Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K(+) channels and Ih.
    Authors: Williams and Hablitz
    Front Cell Neurosci 2015;9:89
  3. Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala.
    Authors: Ferreira Et al.
    PLoS One 2015;9:161
  4. A Cambrian origin for vertebrate rods.
    Authors: Asteriti Et al.
    Elife 2015;4
  5. Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation.
    Authors: Kashyap Et al.
    Front Cell Neurosci 2015;2
  6. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    J Neurophysiol 2015;10:e0132884
  7. Hcn1 is a tremorgenic genetic component in a rat model of essential tremor.
    Authors: Ohno Et al.
    J Neurosci 2015;10:e0123529
  8. Hyperpolarization-activated cyclic nucleotide-gated channels and cAMP-dependent modulation of exocytosis in cultured rat lactotrophs.
    Authors: Calejo Et al.
    J Neurosci 2014;34:15638
  9. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.
    Authors: Dragicevic Et al.
    Bladder (San Franc) 2014;137:2287
  10. Directional summation in non-direction selective retinal ganglion cells.
    Authors: Abbas Et al.
    PLoS Comput Biol 2013;9:e1002969
  11. Inhibition-induced theta resonance in cortical circuits.
    Authors: Stark Et al.
    Neuron 2013;80:1263
  12. Molecular mechanisms that drive estradiol-dependent burst firing of Kiss1 neurons in the rostral periventricular preoptic area.
    Authors: Zhang Et al.
    Am J Physiol Endocrinol Metab 2013;305:E1384
  13. Frequency-selective exocytosis by ribbon synapses of hair cells in the bullfrog's amphibian papilla.
    Authors: Patel Et al.
    Exp Physiol 2012;32:13433
  14. Population diversity and function of hyperpolarization-activated current in olfactory bulb mitral cells.
    Authors: Angelo and Margrie
    Sci Rep 2012;1:50
  15. Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release.
    Authors: Few Et al.
    Proc Natl Acad Sci U S A 2012;109:E452
  16. High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents.
    Authors: Ma Et al.
    J Biomed Sci 2011;301:H2006
  17. Rapid developmental maturation of neocortical FS cell intrinsic excitability.
    Authors: Goldberg Et al.
    J Neurosci 2011;21:666
  18. Downregulation of dendritic HCN channel gating in epilepsy is mediated by altered phosphorylation signaling.
    Authors: Jung Et al.
    J Neurosci 2010;30:6678
  19. Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice.
    Authors: Chen Et al.
    J Neurosci 2010;30:2611
  20. Complex intrinsic membrane properties and dopamine shape spiking activity in a motor axon.
    Authors: Ballo and Bucher
    J Neurosci 2009;29:5062
  21. Developmental expression of a functional TASK-1 2P domain K+ channel in embryonic chick heart.
    Authors: Zhang Et al.
    J Neurosci 2009;16:104
  22. Electrophysiological properties of octopus neurons of the cat cochlear nucleus: an in vitro study.
    Authors: Bal and Baydas
    J Assoc Res Otolaryngol 2009;10:281
  23. Ionic factors governing rebound burst phenotype in rat deep cerebellar neurons.
    Authors: Molineux Et al.
    Cereb Cortex 2008;100:2684
  24. Ih without Kir in adult rat retinal ganglion cells.
    Authors: Lee and Ishida
    J Neurophysiol 2007;97:3790
  25. Local and global effects of I(h) distribution in dendrites of mammalian neurons.
    Authors: Angelo Et al.
    Am J Physiol Heart Circ Physiol 2007;27:8643
  26. A calcium-activated nonselective cation conductance underlies the plateau potential in rat substantia nigra GABAergic neurons.
    Authors: Lee and Tepper
    J Neurosci 2007;27:6531
  27. Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum.
    Authors: Narushima Et al.
    PLoS One 2007;27:496
  28. Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation.
    Authors: Bender Et al.
    J Neurosci 2007;27:4697
  29. Dopamine reduces odor- and elevated-K(+)-induced calcium responses in mouse olfactory receptor neurons in situ.
    Authors: Hegg and Lucero
    J Neurophysiol 2004;91:1492
  30. Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers.
    Authors: Doan Et al.
    Brain 2004;24:3335
Expand to show all 30 Citations

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