Sino-atrial node function modulator; blocks the hyperpolarization activated cation current If
(HCN channel). Blocks Ih
in central neurons. Increases NMDA-evoked noradrenalin release in rat brain in vitro
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Inhibitory actions of ZENECA ZD7288 on whole cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells.
BoSmith et al.
Ih channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices.
Klar et al.
Naunyn Schmiedebergs Arch.Pharmacol., 2003;367:422
Pharmacological characterization of the inwardly rectifying current in the smooth muscle cells of the rat bladder.
Green et al.
Mechanism of block by ZD7288 of the hyperpolarization-activated inward rectifying current in guinea-pig substantia nigra neurons in vitro.
Harris and Constanti
The citations listed below are publications that use Tocris products. Selected citations for ZD 7288 include:
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