Chemical Name: 4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride
Biological ActivityZD 7288 is a sino-atrial node function modulator; blocks the hyperpolarization activated cation current If (HCN channel). Blocks Ih in central neurons. Increases NMDA-evoked noradrenaline release in rat brain in vitro.
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Pharmacological characterization of the inwardly rectifying current in the smooth muscle cells of the rat bladder.
Green et al.
Inhibitory actions of ZENECA ZD7288 on whole cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells.
BoSmith et al.
Mechanism of block by ZD7288 of the hyperpolarization-activated inward rectifying current in guinea-pig substantia nigra neurons in vitro.
Harris and Constanti
Ih channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices.
Klar et al.
Naunyn Schmiedebergs Arch.Pharmacol., 2003;367:422
Citations for ZD 7288
The citations listed below are publications that use Tocris products. Selected citations for ZD 7288 include:
55 Citations: Showing 1 - 10
Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
Authors: Lopez Et al.
Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation.
Authors: Zhang Et al.
Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.
Authors: Collins Et al.
Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region.
Authors: Zhao Et al.
Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors.
Authors: Harris Et al.
J Neurosci 2018;38:8922
Insights into the molecular mechanism for hyperpolarization-dependent activation of HCN channels.
Authors: Flynn and Zagotta
Proc Natl Acad Sci U S A 2018;115:E8086
M-current inhibition rapidly induces a unique CK2-dependent plasticity of the axon initial segment.
Proc Natl Acad Sci U S A 2017;114(47):E10234
Electrophysiological characterization of the M-current in rat hypoglossal motoneurons
Authors: Ghezzi Et al.
Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP(-/-) Mice.
Authors: Fan Et al.
Front Cell Neurosci 2016;10:74
Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K(+) channels and Ih.
Authors: Williams and Hablitz
Front Cell Neurosci 2015;9:89
Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala.
Authors: Ferreira Et al.
PLoS One 2015;9:161
A Cambrian origin for vertebrate rods.
Authors: Asteriti Et al.
Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation.
Authors: Kashyap Et al.
Front Cell Neurosci 2015;2
Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
Authors: Merino Et al.
J Neurophysiol 2015;10:e0132884
Hcn1 is a tremorgenic genetic component in a rat model of essential tremor.
Authors: Ohno Et al.
J Neurosci 2015;10:e0123529
Hyperpolarization-activated cyclic nucleotide-gated channels and cAMP-dependent modulation of exocytosis in cultured rat lactotrophs.
Authors: Calejo Et al.
J Neurosci 2014;34:15638
DA modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels.
Authors: Cilz Et al.
Cereb Cortex 2014;24:3195
Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra DA neurons.
Authors: Dragicevic Et al.
Bladder (San Franc) 2014;137:2287
Directional summation in non-direction selective retinal ganglion cells.
Authors: Abbas Et al.
PLoS Comput Biol 2013;9:e1002969
Contribution of d1/5 receptor modulation of post-spike/burst afterhyperpolarization to enhance neuronal excitability of layer v pyramidal neurons in prepubertal rat prefrontal cortex.
Authors: Yi Et al.
PLoS One 2013;8:e71880
NE drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors.
Authors: Zhang Et al.
PLoS One 2013;8:e66122
Inhibition-induced theta resonance in cortical circuits.
Authors: Stark Et al.
Molecular mechanisms that drive E2-dependent burst firing of Kiss1 neurons in the rostral periventricular preoptic area.
Authors: Zhang Et al.
Am J Physiol Endocrinol Metab 2013;305:E1384
MPP(+) -dependent inhibition of Ih reduces spontaneous activity and enhances EPSP summation in nigral DA neurons.
Authors: Masi Et al.
Br J Pharmacol 2013;169:130
Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells.
Authors: Boehlen Et al.
J Neurophysiol 2013;109:445
Frequency-selective exocytosis by ribbon synapses of hair cells in the bullfrog's amphibian papilla.
Authors: Patel Et al.
Exp Physiol 2012;32:13433
Population diversity and function of hyperpolarization-activated current in olfactory bulb mitral cells.
Authors: Angelo and Margrie
Sci Rep 2012;1:50
Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release.
Authors: Few Et al.
Proc Natl Acad Sci U S A 2012;109:E452
High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents.
Authors: Ma Et al.
J Biomed Sci 2011;301:H2006
Cyclic AMP signaling control of action potential firing rate and molecular circadian pacemaking in the suprachiasmatic nucleus.
Authors: Atkinson Et al.
J Biol Rhythms 2011;26:210
Rapid developmental maturation of neocortical FS cell intrinsic excitability.
Authors: Goldberg Et al.
J Neurosci 2011;21:666
Perineural dexmed. added to ropiva. for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current.
Authors: Brummett Et al.
Electrophysiological effects of SKF83959 on hippocampal CA1 pyramidal neurons: potential mechanisms for the drug's neuroprotective effects.
Authors: Chu Et al.
PLoS One 2010;5
Orchestration of "presto" and "largo" synchrony in up-down activity of cortical networks.
Authors: Gullo Et al.
Front Neural Circuits 2010;4:11
Downregulation of dendritic HCN channel gating in epilepsy is mediated by altered phosphorylation signaling.
Authors: Jung Et al.
J Neurosci 2010;30:6678
Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice.
Authors: Chen Et al.
J Neurosci 2010;30:2611
Complex intrinsic membrane properties and DA shape spiking activity in a motor axon.
Authors: Ballo and Bucher
J Neurosci 2009;29:5062
Developmental expression of a functional TASK-1 2P domain K+ channel in embryonic chick heart.
Authors: Zhang Et al.
J Neurosci 2009;16:104
Electrophysiological properties of octopus neurons of the cat cochlear nucleus: an in vitro study.
Authors: Bal and Baydas
J Assoc Res Otolaryngol 2009;10:281
Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus.
Authors: Safiulina Et al.
J Physiol 2008;586:5437
Dynamic metabotropic control of intrinsic firing in cerebellar unipolar brush cells.
Authors: Russo Et al.
J Neurophysiol 2008;100:3351
Ionic factors governing rebound burst phenotype in rat deep cerebellar neurons.
Authors: Molineux Et al.
Cereb Cortex 2008;100:2684
Ih without Kir in adult rat retinal ganglion cells.
Authors: Lee and Ishida
J Neurophysiol 2007;97:3790
Local and global effects of I(h) distribution in dendrites of mammalian neurons.
Authors: Angelo Et al.
Am J Physiol Heart Circ Physiol 2007;27:8643
A calcium-activated nonselective cation conductance underlies the plateau potential in rat substantia nigra GABAergic neurons.
Authors: Lee and Tepper
J Neurosci 2007;27:6531
Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum.
Authors: Narushima Et al.
PLoS One 2007;27:496
Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation.
Authors: Bender Et al.
J Neurosci 2007;27:4697
Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons.
Authors: Brager and Johnston
J Neurosci 2007;27:13926
Noradrenergic modulation of XII motoneuron inspiratory activity does not involve alpha2-receptor inhibition of the Ih current or presynaptic glutamate release.
Authors: Adachi Et al.
J Appl Physiol (1985) 2005;98:1297
cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction.
Authors: Zhong and Zucker
J Neurosci 2005;25:208
DA reduces odor- and elevated-K(+)-induced calcium responses in mouse olfactory receptor neurons in situ.
Authors: Hegg and Lucero
J Neurophysiol 2004;91:1492
HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons.
Authors: Chan Et al.
J Neurosci 2004;24:9921
Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers.
Authors: Doan Et al.
Frequency-dependent modulation of retinogeniculate transmission by serotonin.
Authors: Seeburg Et al.
J Neurosci 2004;24:10950
Characterization of the human HCN1 channel and its inhibition by capsazepine.
Authors: Gill Et al.
Br J Pharmacol 2004;143:411
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