Chemical Name: 2-(4-Hydroxyphenyl)-3-methyl-1-[10-(pentylsulfonyl)decyl]-1H-indol-5-ol
Biological ActivityZK 164015 is a potent estrogen receptor silent antagonist. Inhibits 17β-estradiol stimulation of luciferase activity (IC50 = 0.025 μM); potently inhibits the growth of estrogen-sensitive human MCF-7 breast cancer cells in vitro (IC50 ~ 1 nM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The anti-estrogen hydroxytamoxifen is a potent antagonist in a novel yeast system.
Liu et al.
Synthesis and biological evaluation of stilbene-based pure estrogen antagonists.
Walter et al.
2-Phenylindoles with sulfur containing side chains. Estrogen receptor affinity, antiestrogenic potency, and antitumour activity.
Biberger and von Angerer
J.Steroid Biochem.Molec.Biol., 1996;58:31
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