ZK 164015

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2183/50
ZK 164015 | CAS No. 177583-70-9 | Estrogen and Related Receptor Antagonists
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Description: Potent estrogen receptor antagonist

Chemical Name: 2-(4-Hydroxyphenyl)-3-methyl-1-[10-(pentylsulfonyl)decyl]-1H-indol-5-ol

Purity: ≥99%

Product Details
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Biological Activity

Potent estrogen receptor silent antagonist. Inhibits 17β-estradiol stimulation of luciferase activity (IC50 = 0.025 μM); potently inhibits the growth of estrogen-sensitive human MCF-7 breast cancer cells in vitro (IC50 ~ 1 nM).

Technical Data

M.Wt:
513.73
Formula:
C30H43NO4S
Solubility:
Soluble to 25 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
177583-70-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The anti-estrogen hydroxytamoxifen is a potent antagonist in a novel yeast system.
    Liu et al.
    Biol.Chem., 1999;380:1341
  2. Synthesis and biological evaluation of stilbene-based pure estrogen antagonists.
    Walter et al.
    Bioorg.Med.Chem.Lett., 2004;14:4659
  3. 2-Phenylindoles with sulfur containing side chains. Estrogen receptor affinity, antiestrogenic potency, and antitumour activity.
    Biberger and von Angerer
    J.Steroid Biochem.Molec.Biol., 1996;58:31

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