Autotaxin Inhibitors Small Molecules and Peptides

Autotaxin (also known as nucleotide pyrophosphatase-phosphodiesterase 2, NPP2) is a secreted enzyme with lysophospholipase D activity and is the primary enzyme responsible for generating lysophosphatidic acid (LPA).

Autotaxin activity encourages cell growth, survival, migration and angiogenesis via its synthesis of LPA and because of this, autotaxin is a target of interest for cancer therapy. Increased expression levels of autotaxin are often observed in several different malignancies; ...