HA 130

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HA 130 | CAS No. 1229652-21-4 | Autotaxin Inhibitors
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Description: Potent and selective autotaxin inhibitor

Chemical Name: B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Potent and selective autotaxin inhibitor (IC50 = 28 nM). Binds and inhibits autotaxin reversibly. Displays no activity against the proteasome, recombinant NPP1 or alkaline phosphatase. Inhibits ATX-mediated cell migration in an A2058 melanoma cell assay.

Technical Data

M.Wt:
463.29
Formula:
C24H19BFNO5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1229652-21-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery and optimization of boronic acid based inhibitors of autotaxin.
    Albers et al.
    J.Med.Chem., 2010;53:4958
  2. Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation.
    Albers et al.
    Proc.Natl.Acad.Sci.USA, 2010;107:7257

Product Datasheets

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Citation for HA 130

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