Chemical Name: B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid
Biological ActivityHA 130 is a potent and selective autotaxin inhibitor (IC50 = 28 nM). Binds and inhibits autotaxin reversibly. Displays no activity against the proteasome, recombinant NPP1 or alkaline phosphatase. Inhibits ATX-mediated cell migration in an A2058 melanoma cell assay.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery and optimization of boronic acid based inhibitors of autotaxin.
Albers et al.
Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation.
Albers et al.
Citation for HA 130
The citations listed below are publications that use Tocris products. Selected citations for HA 130 include:
1 Citation: Showing 1 - 1
The Autotaxin-Lysophosphatidic Acid Axis Modulates Histone Acetylation and Gene Expression during Oligodendrocyte Differentiation.
Authors: Wheeler Et al.
J Neurosci 2015;35:11399
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