Catalog Number: 4196
Chemical Name: B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid
Biological Activity
Selective autotaxin inhibitor (IC50 = 28 nM). Binds and inhibits autotaxin reversibly. Displays no activity against the proteasome, recombinant NPP1 or alkaline phosphatase. Inhibits ATX-mediated cell migration in an A2058 melanoma cell assay.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation.
    Albers et al.
    Proc.Natl.Acad.Sci.USA, 2010;107:7257
  2. Discovery and optimization of boronic acid based inhibitors of autotaxin.
    Albers et al.
    J.Med.Chem., 2010;53:4958
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