BID Proteins and Enzymes

BID is a member of the Bcl-2 family of proteins that regulates outer mitochondrial membrane permeability. BID is a proapoptotic member that causes Cytochrome c to be released from the mitochondrial intermembrane space into the cytosol. In healthy cells, BID is cytosolic. In response to Fas Ligand or TNF-alpha, BID is cleaved by Caspase-8 and then r...