Kinesin Modulators Small Molecules and Peptides

Kinesin superfamily proteins (KIFs) are motor proteins that convert chemical energy, typically in the form of ATP, into mechanical force. They act upon microtubules to move vesicles and organelles within cells, cause the beating of flagella and cilia, and act within the mitotic and meiotic spindles to segregate replicated chromosomes to progeny cells.

Generally, kinesins mediate plus-end transport. Kinesins exist as dimers, with a catalytic 'head' domain and a 'stalk/tail' domain ...