Melusin Proteins and Enzymes

Melusin is a 38 kDa cytoplasmic protein that interacts specifically with the cytoplasmic domain of the beta 1 integrin subunit (CD29). It is expressed solely in striated muscle where it detects mechanical stress. The 347 amino acid residue human Melusin contains two amino terminal cysteine-rich repeats that are separated by an intervening sequence.