Nuclear Hormone Receptor 4A Antagonists Small Molecules and Peptides

NR4As are constitutively active and no endogenous ligands have been identified to date. The effects of these receptors are context and tissue dependent, and are governed by their expression levels, post-translational modification and interaction with other transcription factors.

NR4As are key regulators of inflammatory processes and immune homeostasis and are expressed at high levels in chronically inflamed tissues, such as in atherosclerosis, psoriasis, colitis or rheumatoid arthritis. They ...