Chemical Name: 1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane
Biological ActivityDIM-C-pPhOH is a Nur77 (NR4A1) antagonist. Inhibits TGF-β induced cell migration of breast cancer cell lines. Promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines. Mimics effects of Nur77 RNAi silencing.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Activation of Nur77 by selected 1,1-Bis(3-indolyl)-1- (p-substituted phenyl)methanes induces apoptosis through nuclear pathways.
Chintharlapalli et al.
NR4A1 antagonists inhibit 1-Integrin-dependent breast cancer cell migration.
Hedrick et al.
The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells.
Lee et al.
Mol.Cancer Res., 2014;12:527
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