DIM-C-pPhOH

Key Product Details

Product Description

DIM-C-pPhOH is a Nur77 (NR4A1) antagonist. Inhibits TGF-β induced cell migration of breast cancer cell lines. Promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines. Mimics effects of Nur77 RNAi silencing.

Product Specifications for DIM-C-pPhOH

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for DIM-C-pPhOH

The following data is based on the product molecular weight 338.408.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.78 mL	29.55 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hedrick NR4A1 antagonists inhibit 1-Integrin-dependent breast cancer cell migration. Mol.Cell.Biol 2016 PMID: 26929200
• Lee The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Mol.Cancer Res. 2014 PMID: 24515801
• Chintharlapalli Activation of Nur77 by selected 1,1-Bis(3-indolyl)-1- (p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J.Biol.Chem 2005 PMID: 15871945

Product Documents for DIM-C-pPhOH