Home / Integrin beta 6 / Human Integrin  beta 6 PE-conjugated Antibody

Human Integrin  beta 6 PE-conjugated Antibody

Catalog #: FAB4155P
1 Citation Datasheet / COA / SDS

Discontinued Product

FAB4155P has been discontinued.
View all Integrin beta 6 products.
Detection of Integrin beta 6 in HT‑29 Human Cell Line by Flow Cytometry.
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Citations (1)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Integrin  beta 6 PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human Integrin beta 6 in direct ELISAs.
Source
Monoclonal Mouse IgG2B Clone # 437211
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human Integrin alpha V beta 6
Phe31-Val992 (Integrin alpha V) and Gly22-Asn707 (Integrin beta 6)
Accession # P18564 (Integrin beta 6)
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of Integrin beta 6 antibody in HT‑29 Human Cell Line antibody by Flow Cytometry. View Larger

Detection of Integrin beta 6 in HT‑29 Human Cell Line by Flow Cytometry. HT-29 human colon adenocarcinoma cell line was stained with Mouse Anti-Human Integrin beta 6 PE-conjugated Monoclonal Antibody (Catalog # FAB4155P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: Integrin beta 6

Integrin beta 6 (ITG beta 6) is a 95 kDa member of the Integrin beta family. It forms noncovalent heterodimers with Integrin alpha V and appears on epithelia following injury or inflammation. It activates TGF-beta and assists keratinocyte migration. Human Integrin beta 6 is a type I transmembrane glycoprotein that is 767 amino acids (aa) in length. It contains a 688 aa extracellular domain (ECD) (aa 22-709) that incorporates a 241 aa VWF-A domain. Over aa 22-707, human integrin beta 6 ECD shares 90% and 93% aa sequence identity with mouse and pig integrin beta 6 ECD, respectively.

Entrez Gene IDs
3694 (Human); 16420 (Mouse); 311061 (Rat); 102122296 (Cynomolgus Monkey)
Alternate Names
Integrin beta 6; integrin beta-6; integrin, beta 6; ITGB6

Product Datasheets

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Citation for Human Integrin  beta 6 PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Highly invasive melanoma cells activate the vascular endothelium via an MMP-2/integrin alphavbeta5-induced secretion of VEGF-A.
    Am. J. Pathol., 2012-05-31;181(2):693-705.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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