2-Methoxyestradiol

Key Product Details

Product Description

2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.

Product Specifications for 2-Methoxyestradiol

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 2-Methoxyestradiol

The following data is based on the product molecular weight 302.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.61 mL	33.07 mL	66.14 mL
2.5 mM	1.32 mL	6.61 mL	13.23 mL
5 mM	0.66 mL	3.31 mL	6.61 mL
25 mM	0.13 mL	0.66 mL	1.32 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

• Shimada Roles of p38 and c-jun NH₂-terminal kinase-mediated pathways in 2-methoxyOE-induced p53 induction and apoptosis. Carcinogenesis 2003 PMID: 12807754
• LaVallee 2-MethoxyOE inhibits proliferation and induces apoptosis independently of estrogen receptors α and β. Cancer Res. 2002 PMID: 12097276
• LaVallee 2-MethoxyOE up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res. 2003 PMID: 12543804
• D'Amato 2-MethoxyOE, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colch. site. Proc.Natl.Acad.Sci.U.S.A. 1994 PMID: 8171020

Product Documents for 2-Methoxyestradiol