2-Methoxyestradiol

Catalog # Availability Size / Price Qty
1807/10
1807/50
2-Methoxyestradiol | CAS No. 362-07-2 | Apoptosis Inducer Compounds
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Description: Apoptotic and antiangiogenic agent

Chemical Name: (17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.

Technical Data

M.Wt:
302.41
Formula:
C19H26O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
362-07-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for 2-Methoxyestradiol

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