PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118-kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89- and 24-kDa in one of the hallmark events of apoptosis.
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Key Product Details
Features
The 3-aminobenzamide (3-AB) is provided at 200 mM in ethanol as a control inhibitor in PARP Universal Assay Kits. 3-AB will inhibit the activity of PARP-1 at a wide range of concentrations from 2 μM to 10 mM.
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Formulation, Preparation, and Storage
Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: PARP
Long Name
Poly [ADP-ribose] Polymerase
Alternate Names
ADPRT, PARP1, PPOL
Additional PARP Products
Product Documents for 200 mM 3-Aminobenzamide
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Related Research Areas
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