3-AP

Key Product Details

Product Description

3-AP is a ribonucleotide reductase inhibitor. Also an iron chelator. Inhibits leukemia cell growth and acts in synergy with cisplatin (Cat. No.2251). Active in vivo.

Product Specifications for 3-AP

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 3-AP

The following data is based on the product molecular weight 195.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.12 mL	25.61 mL	51.22 mL
5 mM	1.02 mL	5.12 mL	10.24 mL
10 mM	0.51 mL	2.56 mL	5.12 mL
50 mM	0.10 mL	0.51 mL	1.02 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Finch Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv.Enzyme Regul. 1999 PMID: 10470363
• Liu Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. J.Med.Chem. 1992 PMID: 1433178
• Arid Nucleotide metabolism, oncogene-induced senescence and cancer. Cancer Letters 2015 PMID: 24486217

Product Documents for 3-AP