Chemical Name: 2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide
Biological Activity3-AP is a ribonucleotide reductase inhibitor. Also an iron chelator. Inhibits leukemia cell growth and acts in synergy with cisplatin (Cat. No.2251). Active in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone.
Liu et al.
Nucleotide metabolism, oncogene-induced senescence and cancer.
Arid et al.
Cancer Letters, 2015;356:204
Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity.
Finch et al.
Adv.Enzyme Regul., 1999;39:3
Citation for 3-AP
The citations listed below are publications that use Tocris products. Selected citations for 3-AP include:
1 Citation: Showing 1 - 1
Iron-targeting antitumor activity of gal. compounds and novel insights into triapine(®)-metal complexes.
Authors: Chitambar Et al.
Antioxid.Redox Signal. 2013;18:956
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