( 17 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2251
Alternate Names:CDDP
Chemical Name:cis-Diaminodichloroplatinum
Product Details
Citations (17)
Biological Activity
Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α-induced apoptosis.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in water with gentle warming
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products. Selected citations for Cisplatin include:

17 Citations: Showing 1 - 10
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  1. Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time.
    Authors: Chia Et al.
    Nat Commun  2017;8:435
  2. The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
    Authors: Zhang
    Mol Cancer Ther  2017;16(6):1021
  3. Identification of therapeutic targets applicable to clinical strategies in ovarian cancer.
    Authors: Kim Et al.
    BMC Cancer  2016;16:678
  4. SOX4 contributes to the progression of cervical cancer and the resistance to the chemotherapeutic drug through ABCG2.
    Authors: Sun Et al.
    Korean J Pain  2015;6:e1990
  5. A New Rat Model of Cisplatin-induced Neuropathic Pain.
    Authors: Lin Et al.
    Oncotarget  2015;28:236
  6. Combined CDKN1A/TP53 mutation in bladder cancer is a therapeutic target.
    Authors: Liu and Kwiatkowski
    Mol Cancer Ther  2015;14:174
  7. Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1(low) Monocytes.
    Authors: Saja Et al.
    Cell Death Dis  2015;12:1802
  8. Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase.
    Authors: Marcus Et al.
    Mol Pain  2015;11:34
  9. Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer.
    Authors: Szabova Et al.
    Cell Rep  2014;9:e95649
  10. Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance.
    Authors: Kathawala Et al.
    Int J Oncol  2014;44:1634
  11. Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated paclitaxel resistance: a preclinical study.
    Authors: Kathawala Et al.
    Mol Cancer Ther  2014;13:714
  12. Optimization of a cisplatin model of chemotherapy-induced peripheral neuropathy in mice: use of vitamin C and sodium bicarbonate pretreatments to reduce nephrotoxicity and improve animal health status.
    Authors: Guindon Et al.
    Mol Pain  2014;10:56
  13. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Authors: Robinson Et al.
    PLoS One  2013;8:e78641
  14. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.
    Authors: Fard Et al.
    Cell Cycle  2013;13:408
  15. The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB? receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy.
    Authors: Deng Et al.
    Mol Pain  2012;8:71
  16. A high throughput scintillation proximity imaging assay for protein methyltransferases.
    Authors: Ibáñez Et al.
    Comb Chem High Throughput Screen  2012;15:359
  17. Functional characterization of the 19q12 amplicon in grade III breast cancers.
    Authors: Natrajan Et al.
    Breast Cancer Res  2012;14:R53
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