Biological Activity Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α-induced apoptosis.
Soluble to 5 mM in water with gentle warming
Store at RT
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All Tocris products are intended for laboratory research use only.
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