Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma.
Seki et al.
Cancer Chemother.Pharmacol., 2000;45:199
Impairment of both apoptotic and cytoprotective signalings in glioma cells resistant to the combined use of cisplatin and tumor necrosis factor α.
Duan et al.
Clin.Cancer Res., 2004;10:234
Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells.
Nomura et al.
The citations listed below are publications that use Tocris products. Selected citations for Cisplatin include:
Showing Results 1 - 9 of 9