Catalog Number: 2251
Alternate Names: CDDP
Chemical Name: cis-Diaminodichloroplatinum
Biological Activity
Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α-induced apoptosis.
Technical Data
  • M.Wt:
    300.05
  • Formula:
    Cl2H6N2Pt
  • Solubility:
    Soluble to 5 mM in water with gentle warming
  • Storage:
    Store at RT
  • CAS No:
    15663-27-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma.
    Seki et al.
    Cancer Chemother.Pharmacol., 2000;45:199
  2. Impairment of both apoptotic and cytoprotective signalings in glioma cells resistant to the combined use of cisplatin and tumor necrosis factor α.
    Duan et al.
    Clin.Cancer Res., 2004;10:234
  3. Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells.
    Nomura et al.
    Urol.Oncology, 2004;22:453
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cisplatin include:

10 Citations: Showing 1 - 10
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  1. The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
    Authors: Zhang
    Mol Cancer Ther 2017;16(6):1021
  2. SOX4 contributes to the progression of cervical cancer and the resistance to the chemotherapeutic drug through ABCG2.
    Authors: Sun Et al.
    Korean J Pain 2015;6:e1990
  3. A New Rat Model of Cisplatin-induced Neuropathic Pain.
    Authors: Lin Et al.
    Oncotarget 2015;28:236
  4. Combined CDKN1A/TP53 mutation in bladder cancer is a therapeutic target.
    Authors: Liu and Kwiatkowski
    Mol Cancer Ther 2015;14:174
  5. Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1(low) Monocytes.
    Authors: Saja Et al.
    Cell Death Dis 2015;12:1802
  6. Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer.
    Authors: Szabova Et al.
    Cell Rep 2014;9:e95649
  7. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Authors: Robinson Et al.
    PLoS One 2013;8:e78641
  8. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.
    Authors: Fard Et al.
    Cell Cycle 2013;13:408
  9. A high throughput scintillation proximity imaging assay for protein methyltransferases.
    Authors: Ibáñez Et al.
    Comb Chem High Throughput Screen 2012;15:359
  10. Functional characterization of the 19q12 amplicon in grade III breast cancers.
    Authors: Natrajan Et al.
    Breast Cancer Res 2012;14:R53

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