A 804598

Catalog # Availability Size / Price Qty
4473/10
4473/50
A 804598 | CAS No. 1125758-85-1 | P2X Receptor Antagonists
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Description: Potent and selective P2X7 antagonist

Chemical Name: N-Cyano-N"-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine

Purity: ≥99%

Product Details
Citations (2)
Supplemental Products
Reviews (1)

Biological Activity

Potent, competitive P2X7 receptor antagonist (IC50 values are 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7 receptors respectively). Selective for P2X7 receptors (IC50 > 5-10 μM for a wide array of cell surface receptors and ion channels). Binds with high affinity (Ki app = 2.4 nM for rat P2X7 receptors).

Technical Data

M.Wt:
315.37
Formula:
C19H17N5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1125758-85-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for A 804598

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A 804598 inhibits LPS-induced inflammation
By Anonymous on 01/22/2019
Application: Species: Mouse

RAW macrophages were stimulated with LPS (200 ng/ml) in the absence or presence of A 804598 (1 μM) or MRS 2578 (100 μM) for 8 h to follow iNOS expression by qPCR. Both compounds inhibited LPS-induced iNOS expression revealing role of purinergic receptors.


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