Home / P2X Receptor Antagonists / A 804598

A 804598

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A 804598 | CAS No. 1125758-85-1 | P2X Receptor Antagonists
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Description: Potent and selective P2X7 antagonist

Chemical Name: N-Cyano-N"-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine

Purity: ≥99%

Product Details
Citations (2)
Supplemental Products
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Potent, competitive P2X7 receptor antagonist (IC50 values are 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7 receptors respectively). Selective for P2X7 receptors (IC50 > 5-10 μM for a wide array of cell surface receptors and ion channels). Binds with high affinity (Ki app = 2.4 nM for rat P2X7 receptors).

Technical Data

M.Wt:
315.37
Formula:
C19H17N5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1125758-85-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for A 804598

The citations listed below are publications that use Tocris products. Selected citations for A 804598 include:

2 Citations: Showing 1 - 2

  1. Connexin-43-dependent ATP release mediates macrophage activation during sepsis.
    Authors: Dosch Et al.
    Elife  2019;8
  2. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.
    Authors: Young Et al.
    Cell Commun Signal  2015;11:113

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VersaClone cDNA Plasmids

Human P2RX7 (AAH11913) VersaClone cDNA

RDC0486

Rat P2X7/P2RX7 (NP_062129) VersaClone cDNA

RDC2259

Reviews for A 804598

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A 804598 inhibits LPS-induced inflammation
By Anonymous on 01/22/2019
Application: Species: Mouse

RAW macrophages were stimulated with LPS (200 ng/ml) in the absence or presence of A 804598 (1 μM) or MRS 2578 (100 μM) for 8 h to follow iNOS expression by qPCR. Both compounds inhibited LPS-induced iNOS expression revealing role of purinergic receptors.

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