A 804598

Tocris Bioscience | Catalog # 4473

Potent and selective P2X7 antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective P2X7 antagonist
View all P2X Receptor Antagonists »

Product Description

A 804598 is a potent, competitive P2X7 receptor antagonist (IC50 values are 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7 receptors respectively). Selective for P2X7 receptors (IC50 > 5-10 μM for a wide array of cell surface receptors and ion channels). Binds with high affinity (Ki app = 2.4 nM for rat P2X7 receptors).

Product Specifications for A 804598

Molecular Weight

315.37

Formula

C19H17N5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-Cyano-N"-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine

CAS Number

1125758-85-1

PubChem ID

53325874

InChI Key

PQYCRDPLPKGSME-AWEZNQCLSA-N

SMILES

C[C@@H](C3=CC=CC=C3)NC(NC2=CC=CC1=NC=CC=C12)=NC#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.54 100

Preparing Stock Solutions for A 804598

The following data is based on the product molecular weight 315.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.17 mL 15.85 mL 31.71 mL
5 mM 0.63 mL 3.17 mL 6.34 mL
10 mM 0.32 mL 1.59 mL 3.17 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 32 publications citing the usage of this product.

Product Documents for A 804598

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 804598

For research use only

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  • A 804598 inhibits LPS-induced inflammation
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Macrophages
    Verified Customer | Posted 01/22/2019
    RAW macrophages were stimulated with LPS (200 ng/ml) in the absence or presence of A 804598 (1 μM) or MRS 2578 (100 μM) for 8 h to follow iNOS expression by qPCR. Both compounds inhibited LPS-induced iNOS expression revealing role of purinergic receptors.
    A 804598 4473

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