Potent, competitive P2X7
receptor antagonist (IC50
values are 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7
receptors respectively). Selective for P2X7
> 5-10 μ
M for a wide array of cell surface receptors and ion channels). Binds with high affinity (Ki app
= 2.4 nM for rat P2X7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors.
Donnelly-Roberts et al.
Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat.
Able et al.
The citations listed below are publications that use Tocris products. Selected citations for A 804598 include:
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