Chemical Name: 6-(4-Methoxy-3-tricyclo[22.214.171.124,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Biological ActivityRetinoic acid analog that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Adapalene: an update on newer comparative studies between the various retinoids.
Pharmacology and chemistry of adap.
Shroot et al.
The synthetic retinoid adap. inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro.
Ocker et al.
Citations for Adapalene
The citations listed below are publications that use Tocris products. Selected citations for Adapalene include:
2 Citations: Showing 1 - 2
Increased dietary intake of vitamin A promotes aortic valve calcification in vivo.
Authors: Huk Et al.
Arterioscler Thromb Vasc Biol 2013;33:285
Retinoic acid enhances TRAIL-induced apoptosis in cancer cells by upregulating TRAIL receptor 1 expression.
Authors: Dhandapani Et al.
Drug Des Devel Ther 2011;71:5245
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