Catalog Number: 2852
Alternate Names: CD 271, Differin
Chemical Name: 6-(4-Methoxy-3-tricyclo[,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Biological Activity
Retinoic acid analog that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacology and chemistry of adapalene.
    Shroot et al.
    J.Am.Acad.Dermatol., 1997;36:S96
  2. Adapalene: an update on newer comparative studies between the various retinoids.
    Int.J.Dermatol., 2000;39:784
  3. The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro.
    Ocker et al.
    Int.J.Cancer, 2003;107:453

The citations listed below are publications that use Tocris products. Selected citations for Adapalene include:

Showing Results 1 - 1 of 1

  1. Retinoic acid enhances TRAIL-induced apoptosis in cancer cells by upregulating TRAIL receptor 1 expression.
    Authors: Dhandapani Et al.
    Drug Des Devel Ther
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