(+)-AJ 76 hydrochloride

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Effects of repeated administration of the preferential DA autoreceptor antagonist, (+)-AJ76, on locomotor activity and brain DA metabolism in the rat.
   Kullingsjo et al.
   Eur.J.Pharmacol., 1991;205:241
3. Resolved cis and trans-2-amino-5-methoxy-1-methyltetralins: central DA receptor agonists and antagonists.
   Johansson et al.
   J.Med.Chem., 1987;30:602
4. The role of DA D₃ compared with DA D₂ receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats.
   Millan et al.
   Psychopharmacology, 2004;174:341
5. Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on DA release and metabolism in vivo.
   Waters et al.
   Eur.J.Pharmacol., 1994;251:181

Product Datasheets