(+)-AJ 76 hydrochloride

Key Product Details

Product Description

(+)-AJ 76 hydrochloride is a dopamine receptor antagonist with preferential action at presynaptic receptors (pK_i values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD₃. hD₄, hD_2S, hD_2L and rD₂ receptors respectively).

Product Specifications for (+)-AJ 76 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (+)-AJ 76 hydrochloride

The following data is based on the product molecular weight 269.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 4 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37.06 mL	185.32 mL	370.63 mL
0.5 mM	7.41 mL	37.06 mL	74.13 mL
1 mM	3.71 mL	18.53 mL	37.06 mL
5 mM	0.74 mL	3.71 mL	7.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Waters Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on DA release and metabolism in vivo. Eur.J.Pharmacol. 1994 PMID: 8149975
• Kullingsjo Effects of repeated administration of the preferential DA autoreceptor antagonist, (+)-AJ76, on locomotor activity and brain DA metabolism in the rat. Eur.J.Pharmacol. 1991 PMID: 1817961
• Millan The role of DA D₃ compared with DA D₂ receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats. Psychopharmacology 2004 PMID: 14985929
• Johansson Resolved cis and trans-2-amino-5-methoxy-1-methyltetralins: central DA receptor agonists and antagonists. J.Med.Chem. 1987 PMID: 3560156

Product Documents for (+)-AJ 76 hydrochloride