Catalog Number: 0678
Chemical Name: (1S,2R)-cis-5-Methoxy-1-methyl-2-(N-propylamino)tetralin hydrochloride
Biological Activity
Dopamine receptor antagonist with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD3. hD4, hD2S, hD2L and rD2 receptors respectively).
Technical Data
  • M.Wt:
    269.81
  • Formula:
    C15H23NO.HCl
  • Solubility:
    Soluble to 10 mM in water
  • Storage:
    Store at RT
  • CAS No:
    85378-82-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Resolved cis and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists.
    Johansson et al.
    J.Med.Chem., 1987;30:602
  2. Effects of repeated administration of the preferential dopamine autoreceptor antagonist, (+)-AJ76, on locomotor activity and brain DA metabolism in the rat.
    Kullingsjo et al.
    Eur.J.Pharmacol., 1991;205:241
  3. Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on dopamine release and metabolism in vivo.
    Waters et al.
    Eur.J.Pharmacol., 1994;251:181
  4. The role of dopamine D3 compared with dopamine D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats.
    Millan et al.
    Psychopharmacology, 2004;174:341

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