Alda 1
Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
Purity: ≥99%
Biological Activity
Alda 1 is an activator of aldehyde dehydrogenase 2 (ALDH2). Increases activity of wild-type ALDH2*1 and variant ALDH2*2 (by ~2-fold and 11-fold respectively). Capable of partly restoring mutant ALDH2*2 activity; protective against cardiac ischemia.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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An activator of mutant and wildtype aldehyde dehydrogenase reduces ischemic damage to the heart.
Chen et al.
Science, 2008;321:1493 -
Characterization of the East Asian variant of aldehyde dehydrogenase-2. Bioactivation of nitrogly. and effects of alda-1.
Beretta et al.
J.Biol.Chem., 2010;285:943
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