AM 1172

Catalog # Availability Size / Price Qty
3381/10
Cannabinoid Transporter Inhibitors Small Molecule
1 Image
Description: Anandamide uptake inhibitor; also FAAH inhibitor and CB receptor partial agonist

Chemical Name: N-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-4-hydroxybenzamide

Purity: ≥98%

Product Details
Reviews

Biological Activity

Metabolically stable anandamide uptake inhibitor (IC50 = 2.1 - 2.5 μM) and fatty acid amide hydrolase (FAAH) inhibitor (Ki = 3.18 μM). Inhibits N-arachidonylethanolamine (AEA) accumulation (IC50 = 24 μM) and hydrolysis (Ki = 3 μM), and inhibits N-palmitoylethanolamine (PEA) hydrolysis (IC50 = 36 μM) in cerebellar granule neurons. Also acts as a non-selective cannabinoid receptor partial agonist (EC50 values are 189 and 271 nM at CB2 and CB1 receptors respectively).

Technical Data

M.Wt:
409.6
Formula:
C27H39NO2
Solubility:
Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 10mg/ml)
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
251908-92-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase.
    Kaczocha et al.
    J.Biol.Chem., 2006;281:9066
  2. Studies of anandamide accumulation inhibitors in cerebellar granule neurons.
    Hillard et al.
    J.Mol.Neurosci., 2007;33:18
  3. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172.
    Fegley et al.
    Proc.Natl.Acad.Sci.USA, 2004;101:8756

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for AM 1172

There are currently no reviews for this product. Be the first to review AM 1172 and earn rewards!

Have you used AM 1172?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.