AM 1172
Tocris Bioscience | Catalog # 3381
Anandamide uptake inhibitor; also FAAH inhibitor and CB receptor partial agonist
Discontinued Product
3381 has been discontinued.
View all Cannabinoid Transporter Inhibitors products.
Key Product Details
Description
Anandamide uptake inhibitor; also FAAH inhibitor and CB receptor partial agonist
Product Description
AM 1172 is a metabolically stable anandamide uptake inhibitor (IC50 = 2.1 - 2.5 μM) and fatty acid amide hydrolase (FAAH) inhibitor (Ki = 3.18 μM). Inhibits N-arachidonylethanolamine (AEA) accumulation (IC50 = 24 μM) and hydrolysis (Ki = 3 μM), and inhibits N-palmitoylethanolamine (PEA) hydrolysis (IC50 = 36 μM) in cerebellar granule neurons. Also acts as a non-selective cannabinoid receptor partial agonist (EC50 values are 189 and 271 nM at CB2 and CB1 receptors respectively). FABP inhibitor.
Product Specifications for AM 1172
Molecular Weight
409.60
Formula
C27H39NO2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-4-hydroxybenzamide
CAS Number
251908-92-6
PubChem ID
10364179
InChI Key
XCWBOAHOJHPWLA-DOFZRALJSA-N
SMILES
CCCCC\C=C/C\C=C/C/C=C\C/C=C\CCCCNC(C1=CC=C(O)C=C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Solubility
| Solubility | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 10mg/ml) |
Calculators
Background References
References are publications that support the biological activity of the product.
- Deutsch A personal retrospective: Elevating Anandamide (AEA) by targeting fatty acid amide hydrolase (FAAH) and the fatty acid binding proteins (FABPs). Front.Pharmacol. 2016 PMID: 27790143
- Hillard Studies of anandamide accumulation inhibitors in cerebellar granule neurons. J.Mol.Neurosci. 2007 PMID: 17901541
- Fegley Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc.Natl.Acad.Sci.USA
- Kaczocha Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. J.Biol.Chem. 2006 PMID: 16461355
Product Documents for AM 1172
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for AM 1172
For research use only
Related Research Areas
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