AMG 517

Tocris Bioscience | Catalog # 5995

Potent TRPV1 antagonist
Tocris Bioscience

Key Product Details

Description

Potent TRPV1 antagonist
View all TRPV Antagonists »

Product Description

AMG 517 is a potent TRPV1 antagonist (IC50 = 0.9 nM). Inhibits capsaican-induced flinching and reverses analgesia in an inflammatory pain model in rats. Orally bioavailable.

Product Specifications for AMG 517

Molecular Weight

430.41

Formula

C20H13F3N4O2S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[4-[[6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]acetamide

CAS Number

659730-32-2

PubChem ID

16007367

InChI Key

YUTIXVXZQIQWGY-UHFFFAOYSA-N

SMILES

O=C(NC(S1)=NC(C1=CC=C2)=C2OC3=NC=NC(C4=CC=C(C(F)(F)F)C=C4)=C3)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.3 10

Preparing Stock Solutions for AMG 517

The following data is based on the product molecular weight 430.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.23 mL 116.17 mL 232.34 mL
0.5 mM 4.65 mL 23.23 mL 46.47 mL
1 mM 2.32 mL 11.62 mL 23.23 mL
5 mM 0.46 mL 2.32 mL 4.65 mL

Calculators

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Product Documents for AMG 517

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AMG 517

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for AMG 517 (1)

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  • AMG517 blocks TRPV1 function
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 01/10/2018
    AMG517 should be used at the dose of 30mg/kg in in vivo experiments
    AMG517 was used to relieve SADBE-induced chronic itch in mice via inhibition of TRPV1 function.
    AMG 517 5995

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