17 results for "TRPV Antagonists" in Products
TRPV Antagonists
TRPV channels are so called as a result of their activation by a group of compounds known as vanilloids, which includes capsaicin, compound found in chilli peppers. Capsaicin binds to TRPV1 channels and this binding is responsible for the hot, pain-like sensation caused by eating a spicy chilli.
Like all TRP channels, TRPV channels are cation selective ion channels formed from four individual subunits. They can exist as homo or heterotetramers and display extremely complex activation ...
TRPV antagonist; also activator of ENaCδ
| Chemical Name: | N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide |
| Purity: | ≥98% |
Potent and selective TRPV1 competitive antagonist
| Chemical Name: | (2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide |
| Purity: | ≥98% |
Non-selective CaV2.1 and 2.2 blocker; also blocks TRPV channels
| Chemical Name: | Ammoniated ruthenium oxychloride |
Potent and selective TRPV4 antagonist
| Chemical Name: | 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide |
| Purity: | ≥98% |
Potent and selective TRPV4 antagonist; orally active
| Chemical Name: | 3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide |
| Purity: | ≥98% |
Antiallergic; inhibits inflammatory mediator release from mast cells
| Chemical Name: | 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid |
| Purity: | ≥98% |
Potent and selective TRPV1 competitive antagonist
| Chemical Name: | 4'-Chloro-3-methoxycinnamanilide |
| Purity: | ≥98% |
Reversible, competitive and potent TRPV1 antagonist
| Chemical Name: | 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide |
| Purity: | ≥98% |
Selective TRPV4 antagonist
| Chemical Name: | 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide |
Selective TRPV3 antagonist; brain penetrant
| Chemical Name: | (αS)-α-[cis-3-Hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-2-pyridinemethanol |
| Purity: | ≥98% |
TRPV1 antagonist
| Chemical Name: | 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide |
| Purity: | ≥98% |
Potent and selective TRPV1 antagonist
| Chemical Name: | 3,6-Dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-[1(2H),2'-bipyridine]-4-carboxamide |
| Purity: | ≥98% |
Potent and selective TRPV1 antagonist
| Chemical Name: | 3-Amino-5-[[2-[(2-methoxyethyl)amino]-6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2(1H)-quinoxalinone |
| Purity: | ≥97% |
Potent and selective TRPV4 antagonist
| Chemical Name: | N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride |
| Purity: | ≥98% |
Potent TRPV1 antagonist
| Chemical Name: | N-5-Isoquinolinyl-N'-[[(4-(trifluoromethyl)phenyl]methyl]urea |
| Purity: | ≥98% |
Potent TRPV1 antagonist
| Chemical Name: | N-[4-[[6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]acetamide |
| Purity: | ≥98% |
Selective TRPV2 antagonist
| Chemical Name: | N-(2-Furanylmethyl)-3-[[4-(methylpropylamino)-6-(trifluoromethyl)-2-pyrimidinyl]thio]propanamide |
| Purity: | ≥98% |
