Chemical Name: 2-[(3-Aminopropyl)amino]ethanethiol dihydrogen phosphate
Biological ActivityCytoprotectant against chemotherapy and radiotherapy. Reduces mitochondrial pyruvate use in hepatocytes but not hepatoma cells in vitro. Also inhibits angiogenesis.
Active metabolite is also available, WR 1065 (Cat. No. 3356)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Normal tissue radioprotection by amifostine via Warburg-type effects.
Koukourakis MI, Giatromanolaki A, Zois CE et al.
Amifostine inhibits angiogenesis in vivo.
Giannopoulou et al.
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