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Amifostine

Catalog #: 6655 Datasheet / COA / SDS

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6655 has been discontinued.
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Amifostine | CAS No. 20537-88-6 | General Laboratory Research Reagent
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Description: Cytoprotectant

Chemical Name: 2-[(3-Aminopropyl)amino]ethanethiol dihydrogen phosphate

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Biological Activity

Amifostine is a cytoprotectant against chemotherapy and radiotherapy. Reduces mitochondrial pyruvate use in hepatocytes but not hepatoma cells in vitro. Also inhibits angiogenesis.

Active metabolite is also available, WR 1065 (Cat. No. 3356)

Technical Data

M.Wt:
214.22
Formula:
C5H15N2O3PS
Solubility:
Soluble to 100 mM in water
Storage:
Store at +4°C
CAS No:
20537-88-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. AmiF. inhibits angiogenesis in vivo.
    Giannopoulou et al.
    J.Pharmacol.Exp.Ther., 2003;304:729
  2. Normal tissue radioprotection by AmiF. via Warburg-type effects.
    Koukourakis et al.
    Sci.Rep., 2016;6

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