Amifostine

Key Product Details

Product Description

Amifostine is a cytoprotectant against chemotherapy and radiotherapy. Reduces mitochondrial pyruvate use in hepatocytes but not hepatoma cells in vitro. Also inhibits angiogenesis.

Active metabolite is also available, WR 1065 (Cat. No. 3356)

Product Specifications for Amifostine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Amifostine

The following data is based on the product molecular weight 214.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.67 mL	23.34 mL	46.68 mL
5 mM	0.93 mL	4.67 mL	9.34 mL
10 mM	0.47 mL	2.33 mL	4.67 mL
50 mM	0.09 mL	0.47 mL	0.93 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Koukourakis Normal tissue radioprotection by AmiF. via Warburg-type effects. Sci.Rep. 2016 PMID:  27507219
• Giannopoulou AmiF. inhibits angiogenesis in vivo. J.Pharmacol.Exp.Ther. 2003 PMID: 12538828

Product Documents for Amifostine