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Amifostine

6655 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6655/100
General Laboratory Research Reagent Small Molecule
1 Image
Description: Cytoprotectant

Chemical Name: 2-[(3-Aminopropyl)amino]ethanethiol dihydrogen phosphate

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Biological Activity

Cytoprotectant against chemotherapy and radiotherapy. Reduces mitochondrial pyruvate use in hepatocytes but not hepatoma cells in vitro. Also inhibits angiogenesis.

Active metabolite is also available, WR 1065 (Cat. No. 3356)

Technical Data

M.Wt:
214.22
Formula:
C5H15N2O3PS
Solubility:
Soluble to 100 mM in water
Storage:
Store at +4°C
CAS No:
20537-88-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Normal tissue radioprotection by amifostine via Warburg-type effects.
    Koukourakis MI, Giatromanolaki A, Zois CE et al.
    Sci Rep.
  2. Amifostine inhibits angiogenesis in vivo.
    Giannopoulou et al.
    J.Pharmacol.Exp.Ther., 2003;304:729

Product Datasheets

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