Chemical Name: 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride
Biological ActivityAmiodarone hydrochloride is a broad-spectrum ion channel blocker; blocks late INa, ICa, IKr and IKs and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca2+ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Selectively toxic to NSCs in hESC-derived cell populations.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not DA neurons.
Han et al.
PLoS One., 2009;4:7155
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.
Balgi et al.
PLoS One, 2009;4:e7124
Amiodarone induces cytochrome c release and apoptosis through an iodine-dependent mechanism.
di Matola et al.
Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties.
Antzelevitch et al.
Citation for Amiodarone hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Amiodarone hydrochloride include:
1 Citation: Showing 1 - 1
Amiodarone inhibits apamin-sensitive potassium currents.
Authors: Turker Et al.
PLoS One 2013;8:e70450
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