Catalog Number: 4095
Chemical Name: 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride
Biological Activity
Broad-spectrum ion channel blocker; blocks late INa, ICa, IKr and IKs and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca2+ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Selectively toxic to NSCs in hESC-derived cell populations.
Technical Data
  • M.Wt:
    681.77
  • Formula:
    C25H29I2NO3.HCl
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    19774-82-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.
    Balgi et al.
    PLoS One, 2009;4:e7124
  2. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties.
    Antzelevitch et al.
    Circulation, 2004;110:904
  3. Amiodarone induces cytochrome c release and apoptosis through an iodine-dependent mechanism.
    di Matola et al.
    J.Clin.Endocrin.Metab., 2000;85:4323
  4. Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons.
    Han et al.
    PLoS One., 2009;4:7155
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Amiodarone hydrochloride include:

1 Citations: Showing 1 - 1

  1. Amiodarone inhibits apamin-sensitive potassium currents.
    Authors: Turker Et al.
    PLoS One 2013;8:e70450

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