Broad-spectrum ion channel blocker; blocks late INa
and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca2+
influx in Saccharomyces cerevisiae
and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Selectively toxic to NSCs in hESC-derived cell populations.
Soluble to 50 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.
Balgi et al.
PLoS One, 2009;4:e7124
Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties.
Antzelevitch et al.
Amiodarone induces cytochrome c release and apoptosis through an iodine-dependent mechanism.
di Matola et al.
Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons.
Han et al.
PLoS One., 2009;4:7155
The citations listed below are publications that use Tocris products. Selected citations for Amiodarone hydrochloride include:
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