Amiodarone hydrochloride

Tocris Bioscience | Catalog # 4095

Broad spectrum ion channel blocker; antiarrhythmic
Tocris Bioscience
Discontinued Product
4095 has been discontinued. View all Ion Channel Modulators products.

Key Product Details

Description

Broad spectrum ion channel blocker; antiarrhythmic
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Product Description

Amiodarone hydrochloride is a broad-spectrum ion channel blocker; blocks late INa, ICa, IKr and IKs and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca2+ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Selectively toxic to NSCs in hESC-derived cell populations. Amiodarone depolarizes the resting membrane potential of the triple-negative breast cancer (TNBC) cells and decreases cell migration.

Product Specifications for Amiodarone hydrochloride

Molecular Weight

681.77

Formula

C25H29I2NO3.HCl

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride

CAS Number

19774-82-4

PubChem ID

29770

InChI Key

ITPDYQOUSLNIHG-UHFFFAOYSA-N

SMILES

CCCCC2=C(C(C3=CC(I)=C(OCCN(CC)CC)C(I)=C3)=O)C1=CC=CC=C1O2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.64 20

Preparing Stock Solutions for Amiodarone hydrochloride

The following data is based on the product molecular weight 681.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 7.33 mL 36.67 mL 73.34 mL
1 mM 1.47 mL 7.33 mL 14.67 mL
2 mM 0.73 mL 3.67 mL 7.33 mL
10 mM 0.15 mL 0.73 mL 1.47 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for Amiodarone hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Amiodarone hydrochloride

For research use only

⚠ WARNING: This product can expose you to chemicals including Amiodarone hydrochloride, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Amiodarone hydrochloride

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