Anagrelide hydrochloride
Chemical Name: 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one hydrochloride
Purity: ≥99%
Biological Activity
Anagrelide hydrochloride is a potent type III phosphodiesterase (PDE3) inhibitor (IC50 = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Anagrelide: a potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity.
Gillespie
Biochem.Pharmacol., 1988;37:2866 -
Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans.
Mazur et al.
Blood, 1992;79:1931 -
Comparison of the biological activities of anagr. and its major metabolites in haematopoietic cell cultures.
Wang et al.
Br.J.Pharmacol., 2005;146:324
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