Biological ActivityAntisauvagine-30 is a potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist (Kd values are 1.4 and 153.6 nM for binding to mouse CRF2β and rat CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β cells (pA2 = 8.49). Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo.
(Modifications: Phe-1 = D-Phe, Ile-30 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological and chemical properties of astressin, antisauvagine-30 and α-helCRF: significance for behavioral experiments.
Brauns et al.
Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory.
Sananbenesi et al.
Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2β-selective antisauvagine-30.
Ruhmann et al.
Citations for Antisauvagine-30
The citations listed below are publications that use Tocris products. Selected citations for Antisauvagine-30 include:
2 Citations: Showing 1 - 2
Suppression of piriform cortex activity in rat by corticotropin-releasing factor 1 and serotonin 2A/C receptors.
Authors: Narla Et al.
Hum Mol Genet 2015;9:200
Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal.
Authors: Zhao-Shea Et al.
Front Cell Neurosci 2015;6:6770
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