( 2 citations )    
Product Datasheet
Catalog Number:2071
Alternate Names:[D-Phe11,His12]-Sauvagine (11-40)
Chemical Name:
Product Details
Citations (2)
Biological Activity
Potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist (Kd values are 1.4 and 153.6 nM for binding to mouse CRF2β and rat CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β cells (pA2 = 8.49). Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Phe-1 = D-Phe, Ile-30 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the Max Planck Institute
Product Datasheets
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The citations listed below are publications that use Tocris products. Selected citations for Antisauvagine-30 include:

2 Citations: Showing 1 - 2
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  1. Suppression of piriform cortex activity in rat by corticotropin-releasing factor 1 and serotonin 2A/C receptors.
    Authors: Narla Et al.
    Hum Mol Genet  2015;9:200
  2. Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal.
    Authors: Zhao-Shea Et al.
    Front Cell Neurosci  2015;6:6770


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