Potent, selective and competitive corticotropin-releasing factor CRF2
receptor antagonist (Kd
values are 1.4 and 153.6 nM for binding to mouse CRF2β
and rat CRF1
receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β
= 8.49). Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo
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Pharmacological and chemical properties of astressin, antisauvagine-30 and α-helCRF: significance for behavioral experiments.
Brauns et al.
Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory.
Sananbenesi et al.
Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2β-selective antisauvagine-30.
Ruhmann et al.
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