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Antisauvagine-30

2071 2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2071/1
Antisauvagine-30
1 Image
Description: Potent, selective and competitive CRF2 antagonist
Alternative Names: [D-Phe11,His12]-Sauvagine (11-40)
Product Details
Citations (2)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Antisauvagine-30 is a potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist (Kd values are 1.4 and 153.6 nM for binding to mouse CRF2β and rat CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β cells (pA2 = 8.49). Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo.

Technical Data

M.Wt:
3650.29
Formula:
C161H274N48O46S
Sequence:
FHLLRKMIEIEKQEKEKQQAANNRLLLDTI

(Modifications: Phe-1 = D-Phe, Ile-30 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
220673-95-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of the Max Planck Institute

Background References

  1. Pharmacological and chemical properties of astressin, antisauvagine-30 and α-helCRF: significance for behavioral experiments.
    Brauns et al.
    Neuropharmacology, 2001;41:507
  2. Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory.
    Sananbenesi et al.
    J.Neurosci., 2003;23:11436
  3. Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2β-selective antisauvagine-30.
    Ruhmann et al.
    Proc.Natl.Acad.Sci.USA, 1998;95:15264

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Citations for Antisauvagine-30

The citations listed below are publications that use Tocris products. Selected citations for Antisauvagine-30 include:

2 Citations: Showing 1 - 2

  1. Suppression of piriform cortex activity in rat by corticotropin-releasing factor 1 and serotonin 2A/C receptors.
    Authors: Narla Et al.
    Hum Mol Genet  2015;9:200
  2. Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal.
    Authors: Zhao-Shea Et al.
    Front Cell Neurosci  2015;6:6770

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VersaClone cDNA Plasmids

Human CRHR2 (AAA91320) VersaClone cDNA

RDC0113

Mouse CRHR2 (AAA68026) VersaClone cDNA

RDC0114

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