ARRY 520 trifluoroacetate

Catalog # Availability Size / Price Qty
4676/10
Kinesin Inhibitors Small Molecule
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Description: Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation
Alternative Names: Filanesib

Chemical Name: (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate

Purity: ≥98%

Product Details
Reviews

Biological Activity

Potent kinesin spindle protein (KSP) inhibitor (IC50 = 6 nM); selective for KSP over >250 other receptors and kinases at a concentration of 10 μM. Displays robust antitumor activity in bortezomib-resistant xenografts either alone or in combination with bortezomib. Induces degradation of Mcl-1; exhibits comparable cytotoxic activity to taxol (Cat. No. 1097) in epithelial ovarian cancer cells. Active in vivo.

Technical Data

M.Wt:
420.48
Formula:
C20H22F2N4O2S.CF3CO2H
Solubility:
Soluble to 75 mM in DMSO and to 75 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
885060-09-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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