ARRY 520 trifluoroacetate

Tocris Bioscience | Catalog # 4676

Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation
Tocris Bioscience

Key Product Details

Description

Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation

Alternative Names

Filanesib
View all Kinesin Inhibitors »

Product Description

ARRY 520 trifluoroacetate is a potent kinesin spindle protein (KSP) inhibitor (IC50 = 6 nM); selective for KSP over >250 other receptors and kinases at a concentration of 10 μM. Displays robust antitumor activity in bortezomib-resistant xenografts either alone or in combination with bortezomib. Induces degradation of Mcl-1; exhibits comparable cytotoxic activity to taxol (Cat. No. 1097) in epithelial ovarian cancer cells. Active in vivo.

Product Specifications for ARRY 520 trifluoroacetate

Molecular Weight

420.48

Formula

C20H22F2N4O2S.CF3CO2H

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate

CAS Number

1781834-99-8

PubChem ID

90488964

InChI Key

CIJUJPVFECBUKG-BDQAORGHSA-N

SMILES

FC1=CC=C(F)C=C1C2=NN(C(N(C)OC)=O)[C@](CCCN)([C@]3=CC=CC=C3)S2.FC(F)(F)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.54 75
Ethanol 31.54 75

Preparing Stock Solutions for ARRY 520 trifluoroacetate

The following data is based on the product molecular weight 420.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 3.17 mL 15.85 mL 31.71 mL
3.75 mM 0.63 mL 3.17 mL 6.34 mL
7.5 mM 0.32 mL 1.59 mL 3.17 mL
37.5 mM 0.06 mL 0.32 mL 0.63 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for ARRY 520 trifluoroacetate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ARRY 520 trifluoroacetate

For research use only

Related Research Areas

Microtubules

Citations for ARRY 520 trifluoroacetate

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  • T-ALL Network and Pharmacological Validation of Synthetic Lethal Screen
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: T cell line
    Verified Customer | Posted 03/26/2020
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    ARRY 520 trifluoroacetate 4676

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