ARRY 520 trifluoroacetate
Chemical Name: (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate
Biological ActivityARRY 520 trifluoroacetate is a potent kinesin spindle protein (KSP) inhibitor (IC50 = 6 nM); selective for KSP over >250 other receptors and kinases at a concentration of 10 μM. Displays robust antitumor activity in bortezomib-resistant xenografts either alone or in combination with bortezomib. Induces degradation of Mcl-1; exhibits comparable cytotoxic activity to taxol (Cat. No. 1097) in epithelial ovarian cancer cells. Active in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models.
Woessner et al.
Anticancer Res., 2009;29:4373
Mcl-1 stability determines mitotic cell fate of human multiple myeloma tumor cells treated with the kinesin spindle protein inhibitor ARRY-520.
Tunquist et al.
KSP inhibitor ARRY-520 as a substitute for PacT. in type I ovarian cancer cells.
Kim et al.
Citation for ARRY 520 trifluoroacetate
The citations listed below are publications that use Tocris products. Selected citations for ARRY 520 trifluoroacetate include:
1 Citation: Showing 1 - 1
High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions.
Authors: Mues Et al.
Cell Rep 2019;27:631
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for ARRY 520 trifluoroacetate
Average Rating: 5 (Based on 1 Review)
Have you used ARRY 520 trifluoroacetate?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image