Taxol

Tocris Bioscience | Catalog # 1097

Promotes assembly and inhibits disassembly of microtubules
Tocris Bioscience

Key Product Details

Description

Promotes assembly and inhibits disassembly of microtubules

Alternative Names

Paclitaxel
View all Microtubule Binding Compounds »

Product Description

Taxol, also known as paclitaxel, promotes and stabilizes tubulin polymerization, causing cell cycle arrest. In CCRF-HSB-2 cells, Taxol induces autocatalytic activation of caspase-10, triggering apoptosis. Taxol is an antitumor agent. In a mouse model of bladder cancer Taxol decreases tumor growth. Taxol also prolongs survival of mice transplanted with human ovarian carcinoma xenografts. Taxol improves neurological outcome and magnetic resonance imaging biomarkers after traumatic brain injury in mice.

Product Specifications for Taxol

Molecular Weight

853.92

Formula

C47H51NO14

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

[2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid

CAS Number

33069-62-4

PubChem ID

441276

InChI Key

RCINICONZNJXQF-VAZQATRQSA-N

SMILES

O=C2[C@@]3(C)C([C@@]4(OC(C)=O)[C@H](OC4)C[C@@H]3O)[C@H](OC(C7=CC=CC=C7)=O)[C@@]1(O)[C@](C)(C)C([C@H]2OC(C)=O)=C(C)[C@@H](OC([C@H](O)[C@H]([C@]5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 85.39 100 with gentle warming
Ethanol 21.35 25 with gentle warming

Preparing Stock Solutions for Taxol

The following data is based on the product molecular weight 853.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.17 mL 5.86 mL 11.71 mL
5 mM 0.23 mL 1.17 mL 2.34 mL
10 mM 0.12 mL 0.59 mL 1.17 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 128 publications citing the usage of this product.

Product Documents for Taxol

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Taxol

For research use only

⚠ WARNING: This product can expose you to chemicals including Paclitaxel, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Related Research Areas

Microtubules

Customer Reviews for Taxol (2)

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  • Establishment of chemoresistant cells lines
    Name: MARINA KOUTSIOUMPA
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/13/2022
    Taxol was used for the establishment of taxol-resistant pancreatic cancer cell lines.
  • Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: Human epidermal carcinoma cell line
    Verified Customer | Posted 11/17/2019
    Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.
    Taxol 1097

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