Taxol

Catalog # Availability Size / Price Qty
1097/10
1097/50
Taxol | CAS No. 33069-62-4 | Microtubule Binding Compounds
1 Image
Description: Promotes assembly and inhibits disassembly of microtubules
Alternative Names: Paclitaxel

Chemical Name: [2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid

Purity: ≥99%

Product Details
Citations (27)
Reviews (1)

Biological Activity

Taxol is an antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.

Technical Data

M.Wt:
853.92
Formula:
C47H51NO14
Solubility:
Soluble to 25 mM in ethanol and to 100 mM in DMSO with gentle warming
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
33069-62-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms.
    McGuire et al.
    Ann.Intern.Med., 1989;111:273
  2. Taxol: a novel investigational antimicrotubule agent.
    Rowinsky et al.
    J.Natl.Cancer Inst., 1990;82:1247
  3. Taxol induces caspase-10-dependent apoptosis.
    Park et al.
    J.Biol.Chem., 2004;279:51057
  4. Characterization of the Tax. binding site on the microtubule.
    Rao et al.
    J.Biol.Chem., 1999;274:37990

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⚠ WARNING: This product can expose you to chemicals including Paclitaxel, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Taxol

The citations listed below are publications that use Tocris products. Selected citations for Taxol include:

27 Citations: Showing 1 - 10

  1. Programmed cell death factor 4 enhances the chemosensitivity of colorectal cancer cells to Taxol.
    Authors: Wang Et al.
    Oncol Lett  2019;18:1402
  2. Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN.
    Authors: Kyte Et al.
    J Pharmacol Exp Ther  2018;364:110
  3. Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells.
    Authors: Wang Et al.
    Elife  2017;6
  4. The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
    Authors: Zhang
    Mol Cancer Ther  2017;16(6):1021
  5. Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents.
    Authors: Ayoub
    Onco Targets Ther  2017;10:4869
  6. Gene expression profile of sodium channel subunits in the anterior cingulate cortex during experimental paclitaxel-induced neuropathic pain in mice.
    Authors: Masocha
    PeerJ  2016;4:e2702
  7. σ1 receptor ligands control a switch between passive and active threat responses.
    Authors: Rennekamp Et al.
    Nat Chem Biol  2016;12:552
  8. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study.
    Authors: Kathawala Et al.
    Oncotarget  2015;6:510
  9. Coadministration of indomet. and MinCyc attenuates established PacT.-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors.
    Authors: Parvathy and Masocha
    Proc Natl Acad Sci U S A  2015;5:10541
  10. Bioactivity characterization of Lactobacillus strains isolated from dairy products.
    Authors: Haghshenas Et al.
    Microbiologyopen  2015;4:803
  11. Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during PacT.-induced neuropathic pain in mice.
    Authors: Masocha
    PeerJ  2015;3:e1350
  12. ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel.
    Authors: Kathawala Et al.
    J Cell Sci  2015;34:115
  13. Biopolymer implants enhance the efficacy of adoptive T-cell therapy.
    Authors: Stephan Et al.
    PLoS One  2015;33:97
  14. Transgenic plants as low-cost platform for chemotherapeutic drugs screening.
    Authors: Vergara Et al.
    Chin J Cancer  2015;16:2174
  15. Quantitative analysis of microtubule orientation in interdigitated leaf pavement cells.
    Authors: Akita Et al.
    Int J Mol Sci  2015;10:e1024396
  16. High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction.
    Authors: Goldmacher Et al.
    Plant Signal Behav  2015;10:e0117523
  17. Depletion of the central metabolite NAD leads to oncosis-mediated cell death.
    Authors: Nagro Et al.
    Nat Biotechnol  2014;289:35182
  18. p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs.
    Authors: Habu and Matsumoto
    Sci Rep  2013;2:562
  19. Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1.
    Authors: Floyd Et al.
    EMBO J  2013;126:2845
  20. N-cadherin specifies first asymmetry in developing neurons.
    Authors: Gärtner Et al.
    Springerplus  2012;31:1893
  21. Functional characterization of the 19q12 amplicon in grade III breast cancers.
    Authors: Natrajan Et al.
    Breast Cancer Res  2012;14:R53
  22. PacT. and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells.
    Authors: Lin Et al.
    Br J Cancer  2012;107:1692
  23. Substance P induces the reversible formation of varicosities in the dendrites of rat brainstem neurons.
    Authors: Hahm Et al.
    Brain Res  2011;1369:36
  24. Leading tip drives som. translocation via forward F-actin flow during neuronal migration.
    Authors: He Et al.
    J Neurosci  2010;30:10885
  25. Alpha-tocopheryl succinate potentiates the PacT.-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells.
    Authors: Lim Et al.
    Exp Mol Med  2009;41:737
  26. Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice
    Authors: Nieto Et al.
    Pain  2008;137:520
  27. Potentiation of PacT.-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.
    Authors: Pennati Et al.
    Mol Cancer Ther  2005;4:1328

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Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma
By Anonymous on 11/17/2019
Application: Species: Mouse

Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.

PMID: 28265007

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.