Chemical Name: [2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid
Biological ActivityTaxol, also known as paclitaxel, promotes and stabilizes tubulin polymerization, causing cell cycle arrest. In CCRF-HSB-2 cells, Taxol induces autocatalytic activation of caspase-10, triggering apoptosis. Taxol is an antitumor agent. In a mouse model of bladder cancer Taxol decreases tumor growth. Taxol also prolongs survival of mice transplanted with human ovarian carcinoma xenografts. Taxol improves neurological outcome and magnetic resonance imaging biomarkers after traumatic brain injury in mice.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms.
McGuire et al.
Taxol: a novel investigational antimicrotubule agent.
Rowinsky et al.
J.Natl.Cancer Inst., 1990;82:1247
Taxol induces caspase-10-dependent apoptosis.
Park et al.
Characterization of the Tax. binding site on the microtubule.
Rao et al.
Citations for Taxol
The citations listed below are publications that use Tocris products. Selected citations for Taxol include:
28 Citations: Showing 1 - 10
Paclitaxel in vitro reversibly sensitizes the excitability of IB4(-) and IB4(+) sensory neurons from male and female rats.
Authors: Villalba-Riquelme Et al.
Programmed cell death factor 4 enhances the chemosensitivity of colorectal cancer cells to Taxol.
Authors: Wang Et al.
Oncol Lett 2019;18:1402
Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN.
Authors: Kyte Et al.
J Pharmacol Exp Ther 2018;364:110
Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells.
Authors: Wang Et al.
The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
Mol Cancer Ther 2017;16(6):1021
Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents.
Onco Targets Ther 2017;10:4869
Gene expression profile of sodium channel subunits in the anterior cingulate cortex during experimental paclitaxel-induced neuropathic pain in mice.
σ1 receptor ligands control a switch between passive and active threat responses.
Authors: Rennekamp Et al.
Nat Chem Biol 2016;12:552
The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study.
Authors: Kathawala Et al.
Coadministration of indomet. and MinCyc attenuates established PacT.-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors.
Authors: Parvathy and Masocha
Proc Natl Acad Sci U S A 2015;5:10541
Bioactivity characterization of Lactobacillus strains isolated from dairy products.
Authors: Haghshenas Et al.
Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during PacT.-induced neuropathic pain in mice.
ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel.
Authors: Kathawala Et al.
J Cell Sci 2015;34:115
Biopolymer implants enhance the efficacy of adoptive T-cell therapy.
Authors: Stephan Et al.
PLoS One 2015;33:97
Transgenic plants as low-cost platform for chemotherapeutic drugs screening.
Authors: Vergara Et al.
Chin J Cancer 2015;16:2174
Quantitative analysis of microtubule orientation in interdigitated leaf pavement cells.
Authors: Akita Et al.
Int J Mol Sci 2015;10:e1024396
High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction.
Authors: Goldmacher Et al.
Plant Signal Behav 2015;10:e0117523
Depletion of the central metabolite NAD leads to oncosis-mediated cell death.
Authors: Nagro Et al.
Nat Biotechnol 2014;289:35182
p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs.
Authors: Habu and Matsumoto
Sci Rep 2013;2:562
Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1.
Authors: Floyd Et al.
EMBO J 2013;126:2845
N-cadherin specifies first asymmetry in developing neurons.
Authors: Gärtner Et al.
Functional characterization of the 19q12 amplicon in grade III breast cancers.
Authors: Natrajan Et al.
Breast Cancer Res 2012;14:R53
PacT. and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells.
Authors: Lin Et al.
Br J Cancer 2012;107:1692
Substance P induces the reversible formation of varicosities in the dendrites of rat brainstem neurons.
Authors: Hahm Et al.
Brain Res 2011;1369:36
Leading tip drives som. translocation via forward F-actin flow during neuronal migration.
Authors: He Et al.
J Neurosci 2010;30:10885
Alpha-tocopheryl succinate potentiates the PacT.-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells.
Authors: Lim Et al.
Exp Mol Med 2009;41:737
Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice
Authors: Nieto Et al.
Potentiation of PacT.-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.
Authors: Pennati Et al.
Mol Cancer Ther 2005;4:1328
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