hh Taxol (CAS 33069-62-4): R&D Systems
Catalog Number: 1097
Alternate Names: Paclitaxel
Chemical Name: [2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetr
Biological Activity
Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.
Technical Data
  • M.Wt:
    853.92
  • Formula:
    C47H51NO14
  • Solubility:
    Soluble to 25 mM in ethanol and to 100 mM in DMSO with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    33069-62-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Taxol: a novel investigational antimicrotubule agent.
    Rowinsky et al.
    J.Natl.Cancer Inst., 1990;82:1247
  3. Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms.
    McGuire et al.
    Ann.Intern.Med., 1989;111:273
  4. Taxol induces caspase-10-dependent apoptosis.
    Park et al.
    J.Biol.Chem., 2004;279:51057
  5. Characterization of the taxol binding site on the microtubule.
    Rao et al.
    J.Biol.Chem., 1999;274:37990
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Taxol include:

18 Citations: Showing 1 - 10
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  1. The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
    Authors: Zhang
    Mol Cancer Ther 2017;16(6):1021
  2. Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents.
    Authors: Ayoub
    Onco Targets Ther 2017;10:4869
  3. Coadministration of indomethacin and minocycline attenuates established paclitaxel-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors.
    Authors: Parvathy and Masocha
    Proc Natl Acad Sci U S A 2015;5:10541
  4. Bioactivity characterization of Lactobacillus strains isolated from dairy products.
    Authors: Haghshenas Et al.
    Microbiologyopen 2015;4:803
  5. Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice.
    Authors: Masocha
    PeerJ 2015;3:e1350
  6. ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel.
    Authors: Kathawala Et al.
    J Cell Sci 2015;34:115
  7. Biopolymer implants enhance the efficacy of adoptive T-cell therapy.
    Authors: Stephan Et al.
    PLoS One 2015;33:97
  8. Transgenic plants as low-cost platform for chemotherapeutic drugs screening.
    Authors: Vergara Et al.
    Chin J Cancer 2015;16:2174
  9. Quantitative analysis of microtubule orientation in interdigitated leaf pavement cells.
    Authors: Akita Et al.
    Int J Mol Sci 2015;10:e1024396
  10. High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction.
    Authors: Goldmacher Et al.
    Plant Signal Behav 2015;10:e0117523
  11. Depletion of the central metabolite NAD leads to oncosis-mediated cell death.
    Authors: Nagro Et al.
    Nat Biotechnol 2014;289:35182
  12. p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs.
    Authors: Habu and Matsumoto
    Sci Rep 2013;2:562
  13. Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1.
    Authors: Floyd Et al.
    EMBO J 2013;126:2845
  14. N-cadherin specifies first asymmetry in developing neurons.
    Authors: Gärtner Et al.
    Springerplus 2012;31:1893
  15. Functional characterization of the 19q12 amplicon in grade III breast cancers.
    Authors: Natrajan Et al.
    Breast Cancer Res 2012;14:R53
  16. Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells.
    Authors: Lin Et al.
    Br J Cancer 2012;107:1692
  17. Alpha-tocopheryl succinate potentiates the paclitaxel-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells.
    Authors: Lim Et al.
    Exp Mol Med 2009;41:737
  18. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.
    Authors: Pennati Et al.
    Mol Cancer Ther 2005;4:1328
Expand to show all 18 Citations

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