Catalog Number: 1097
Alternate Names: Paclitaxel
Chemical Name: [2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetr
Biological Activity
Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in ethanol and to 100 mM in DMSO with gentle warming
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Taxol: a novel investigational antimicrotubule agent.
    Rowinsky et al.
    J.Natl.Cancer Inst., 1990;82:1247
  3. Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms.
    McGuire et al.
    Ann.Intern.Med., 1989;111:273
  4. Taxol induces caspase-10-dependent apoptosis.
    Park et al.
    J.Biol.Chem., 2004;279:51057
  5. Characterization of the taxol binding site on the microtubule.
    Rao et al.
    J.Biol.Chem., 1999;274:37990

The citations listed below are publications that use Tocris products. Selected citations for Taxol include:

Showing Results 1 - 10 of 16

  1. Coadministration of indomethacin and minocycline attenuates established paclitaxel-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors.
    Authors: Parvathy and Masocha
    Proc Natl Acad Sci U S A
  2. Bioactivity characterization of Lactobacillus strains isolated from dairy products.
    Authors: Haghshenas Et al.
  3. Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice.
    Authors: Masocha
  4. ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel.
    Authors: Kathawala Et al.
    J Cell Sci
  5. Biopolymer implants enhance the efficacy of adoptive T-cell therapy.
    Authors: Stephan Et al.
    PLoS One
  6. Transgenic plants as low-cost platform for chemotherapeutic drugs screening.
    Authors: Vergara Et al.
    Chin J Cancer
  7. Quantitative analysis of microtubule orientation in interdigitated leaf pavement cells.
    Authors: Akita Et al.
    Int J Mol Sci
  8. High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction.
    Authors: Goldmacher Et al.
    Plant Signal Behav
  9. Depletion of the central metabolite NAD leads to oncosis-mediated cell death.
    Authors: Nagro Et al.
    Nat Biotechnol
  10. p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs.
    Authors: Habu and Matsumoto
    Sci Rep
  11. Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1.
    Authors: Floyd Et al.
    EMBO J
  12. N-cadherin specifies first asymmetry in developing neurons.
    Authors: Gärtner Et al.
  13. Functional characterization of the 19q12 amplicon in grade III breast cancers.
    Authors: Natrajan Et al.
    Breast Cancer Res
  14. Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells.
    Authors: Lin Et al.
    Br J Cancer
  15. Alpha-tocopheryl succinate potentiates the paclitaxel-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells.
    Authors: Lim Et al.
    Exp Mol Med
  16. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.
    Authors: Pennati Et al.
    Mol Cancer Ther
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