Chemical Name: (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
Biological ActivityAntimalarial agent; interacts with heme to produce carbon-centred free radicals, causes protein alkylation and damages parasite microorganelles and membranes. Also selectively inhibits the P-type ATPase (PfATP6) of Plasmodium falciparum (Ki ~ 150 nM). Displays antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Artemisinin and its derivatives. An important new class of antimalarial agents.
Artemisinins target the SERCA of Plasmodium falciparum.
Eckstein-Ludwig et al.
The antimalarial agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies.
Wartenberg et al.
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