Catalog Number: 2668
Alternate Names: Qinghaosu
Chemical Name: (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
Biological Activity
Antimalarial agent; interacts with heme to produce carbon-centred free radicals, causes protein alkylation and damages parasite microorganelles and membranes. Also selectively inhibits the P-type ATPase (PfATP6) of Plasmodium falciparum (Ki ~ 150 nM). Displays antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 75 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Artemisinin and its derivatives. An important new class of antimalarial agents.
    Pharmacol.Ther., 2001;90:261
  2. Artemisinins target the SERCA of Plasmodium falciparum.
    Eckstein-Ludwig et al.
    Nature, 2003;424:957
  3. The antimalarial agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies.
    Wartenberg et al.
    Lab.Invest., 2003;83:1647
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