ASP 3026

Catalog # Availability Size / Price Qty
5310/50
5310/10

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ASP 3026 | CAS No. 1097917-15-1 | ALK Inhibitors
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Description: Potent anaplastic lymphoma kinase (ALK) inhibitor; also potent ACK inhibitor

Chemical Name: N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine

Purity: ≥99%

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Biological Activity

ASP 3026 is a potent anaplastic lymphoma kinase (ALK) inhibitor (IC50 = 3.5 nM). Also inhibits Ack and ROS1 activity (IC50 values are 5.8 and 8.9 nM respectively). Attenuates proliferation, and induces apoptosis of NPM-ALK+ T cell anaplastic large-cell lymphoma (ALCL) cells in vitro. Suppresses tumor growth of NPM-ALK+ ALCL cell xenografts in mice. Causes tumor shrinkage in hEML4-ALK transgenic mice. Orally available.

Technical Data

M.Wt:
580.74
Formula:
C29H40N8O3S
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1097917-15-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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