Human ALK/CD246 (NP_004295) VersaClone cDNA Summary
Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.
No product specific FAQs exist for this product, however you mayView all cDNA Clone FAQs
Reviews for Human ALK/CD246 (NP_004295) VersaClone cDNA
There are currently no reviews for this product. Be the first to review Human ALK/CD246 (NP_004295) VersaClone cDNA and earn rewards!
Have you used Human ALK/CD246 (NP_004295) VersaClone cDNA?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image