Inhibitor of thioredoxin reductase (TrxR) (IC50
= 20 nM; Ki
= 4 nM for the NADPH-reduced form of human cytosolic TrxR). Thought to induce the mitochondrial permeability transition via inhibition of mitochondrial TrxR. Also exhibits anti-inflammatory and immunosuppressive activities; inhibits 5-lipoxygenase at high concentrations and stimulates LTA hydrolase at low concentrations.
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Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1 and STAT3.
Kim et al.
Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative.
Rigobello et al.
Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds.
Gromer et al.
Auranofin stimulates LTA hydrolase and inhibits 5-lipoxygenase/LTA synthase activity of isolated human neutrophils.
Betts et al.