Chemical Name: 1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate
Biological ActivityAuranofin is an inhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Thought to induce the mitochondrial permeability transition via inhibition of mitochondrial TrxR. Also exhibits anti-inflammatory and immunosuppressive activities; inhibits 5-lipoxygenase at high concentrations and stimulates LTA hydrolase at low concentrations. Also inhibits SARS-CoV-2 infection in Huh7 cell line (IC50 = 1.4 μM)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1 and STAT3.
Kim et al.
Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative.
Rigobello et al.
Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds.
Gromer et al.
Auranofin stimulates LTA hydrolase and inhibits 5-lipoxygenase/LTA synthase activity of isolated human neutrophils.
Betts et al.
The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells.
Rothan et al.
Citation for Auranofin
The citations listed below are publications that use Tocris products. Selected citations for Auranofin include:
1 Citation: Showing 1 - 1
Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62.
Authors: Tsai Et al.
J Biol Chem 2015;290:21845
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