Chemical Name: 1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate
Biological Activity Inhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Thought to induce the mitochondrial permeability transition via inhibition of mitochondrial TrxR. Also exhibits anti-inflammatory and immunosuppressive activities; inhibits 5-lipoxygenase at high concentrations and stimulates LTA hydrolase at low concentrations.
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Store at RT
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