AZD 5438

Catalog # Availability Size / Price Qty
3968/10
3968/50
Cyclin-dependent Kinase Inhibitors Small Molecule
1 Image
Description: Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9

Chemical Name: 4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine

Purity: ≥99%

Product Details
Citations (2)
Reviews

Biological Activity

Potent inhibitor of cyclin dependent kinases (cdks; reported IC50 values are 6 - 45, 14, 16 and 20 nM for cdk2, cdk5, cdk1 and cdk9 respectively). Also inhibits cdk4 and cdk7 in the sub micromolar range. Exhibits antiproliferative activity in human tumor cell lines. Blocks cell cycling at G2-M, S and G1 phases; reduces the proportion of actively cycling cells in vivo.

Technical Data

M.Wt:
371.46
Formula:
C18H21N5O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
602306-29-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.

Product Datasheets

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Citations for AZD 5438

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2 Citations: Showing 1 - 2

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