AZM 475271

Catalog # Availability Size / Price Qty
AZM 475271 | CAS No. 476159-98-5 | Src Family Kinase Inhibitors
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Description: Src tyrosine kinase inhibitor

Chemical Name: N-(2-Chloro-5-methoxyphenyl)-6-methoxy

Purity: ≥99%

Product Details
Citations (4)

Biological Activity

AZM 475271 is a src tyrosine kinase inhibitor. Reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Also exhibits antiangiogenic activity in vitro and in vivo. Sensitizes tumor cells to the cytotoxic effects of gemcitabine (Cat. No. 3259).

Technical Data

Soluble to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.

Background References

  1. IL-17E synergizes with EGF and confers in vitro resistance to EGFR-targeted therapies in TNBC cells
    Y Merrouche, J Fabre, H Cure, C Garbar, C Fuselier, J Bastid, F Antonicell, R Al-Daccak, A Bensussan, J Giustinian
    Oncotarget, 2016;7(33):53350-53361.
  2. Inhibition of Src tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice.
    Yezhelyev et al.
    Clin.Cancer Res., 2004;10:8028
  3. AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes.
    Summy et al.
    Mol.Cancer Ther., 2005;4:1900
  4. Activated Leukocyte Cell Adhesion Molecule (ALCAM), a Potential 'Seed' and 'Soil' Receptor in the Peritoneal Metastasis of Gastrointestinal Cancers
    YM Yang, L Ye, F Ruge, Z Fang, K Ji, AJ Sanders, S Jia, C Hao, QP Dou, J Ji, WG Jiang
    International Journal of Molecular Sciences, 2023;24(1):.

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