Src tyrosine kinase inhibitor. Reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Also exhibits antiangiogenic activity in vitro
and in vivo
. Sensitizes tumor cells to the cytotoxic effects of gemcitabine
(Cat. No. 3259).
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Sold with the permission of AstraZeneca UK Ltd.
Inhibition of Src tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice.
Yezhelyev et al.
Clin.Cancer Res., 2004;10:8028
AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes.
Summy et al.
Mol.Cancer Ther., 2005;4:1900
The citations listed below are publications that use Tocris products. Selected citations for AZM 475271 include:
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