AZM 475271

  ( 3 citations )    
Product Datasheet
Catalog Number:3963
Chemical Name:N-(2-Chloro-5-methoxyphenyl)-6-methoxy
Product Details
Citations (3)
Reviews
Biological Activity
Src tyrosine kinase inhibitor. Reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Also exhibits antiangiogenic activity in vitro and in vivo. Sensitizes tumor cells to the cytotoxic effects of gemcitabine (Cat. No. 3259).
Technical Data
  • M.Wt:
    442.94
  • Formula:
    C23H27ClN4O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    476159-98-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AZM 475271 include:

3 Citations: Showing 1 - 3
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  1. Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling.
    Authors: Gautam Et al.
    Mol Cancer  2016;15:75
  2. Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer.
    Authors: Thakur Et al.
    Sci Rep  2015;5:10194
  3. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.
    Authors: Leoni Et al.
    J Clin Invest  2013;123:443

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