Catalog Number: 3963
Chemical Name: N-(2-Chloro-5-methoxyphenyl)-6-methoxy
Biological Activity
Src tyrosine kinase inhibitor. Reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Also exhibits antiangiogenic activity in vitro and in vivo. Sensitizes tumor cells to the cytotoxic effects of gemcitabine (Cat. No. 3259).
Technical Data
  • M.Wt:
    442.94
  • Formula:
    C23H27ClN4O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    476159-98-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
  1. Inhibition of Src tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice.
    Yezhelyev et al.
    Clin.Cancer Res., 2004;10:8028
  2. AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes.
    Summy et al.
    Mol.Cancer Ther., 2005;4:1900
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AZM 475271 include:

1 Citations: Showing 1 - 1

  1. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.
    Authors: Leoni Et al.
    J Clin Invest 2013;123:443

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