Gemcitabine hydrochloride

  ( 11 citations )    
Product Datasheet
Catalog Number:3259
Chemical Name:(+)-2'-Deoxy-2',2'-difluorocytidine hydrochloride
Product Details
Citations (11)
Biological Activity
Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 20 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:

The citations listed below are publications that use Tocris products. Selected citations for Gemcitabine hydrochloride include:

11 Citations: Showing 1 - 10
Filter your results:

  1. Plk1 inhibition enhances the efficacy of gemcitabine in human pancreatic cancer.
    Authors: Li Et al.
    Cell Cycle  2016;15:711
  2. An automated fitting procedure and software for dose-response curves with multiphasic features.
    Authors: Veroli Et al.
    Mol Cancer Ther  2015;5:14701
  3. Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase.
    Authors: Truman Et al.
    J Proteomics  2015;112:285
  4. DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.
    Authors: Dolman Et al.
    PLoS One  2015;10:e0145744
  5. Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells.
    Authors: Okita Et al.
    PLoS One  2015;10:e0139809
  6. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715.
    Authors: Slee Et al.
    Mol Cancer Ther  2014;13:307
  7. BRCA2 and RAD51 promote double-strand break formation and cell death in response to gemcitabine.
    Authors: Jones Et al.
    PLoS One  2014;13:2412
  8. Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo.
    Authors: Bapiro Et al.
    Br J Cancer  2014;111:318
  9. A simple high-content cell cycle assay reveals frequent discrepancies between cell number and ATP and MTS proliferation assays.
    Authors: Chan Et al.
    PLoS One  2013;8:e63583
  10. Characterization of permeability, stability and anti-HIV-1 activity of decitabine and gemcitabine divalerate prodrugs.
    Authors: Clouser Et al.
    Antivir Chem Chemother  2013;23:223
  11. Plk1 phosphorylation of orc2 and hbo1 contributes to gemcitabine resistance in pancreatic cancer.
    Authors: Song Et al.
    Mol Cancer Ther  2013;12:58
Expand to show all Citations


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used Gemcitabine hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order


Customer Information

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee