Chemical Name: (+)-2'-Deoxy-2',2'-difluorocytidine hydrochloride
Biological Activity Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo.
Soluble to 100 mM in water and to 20 mM in DMSO
Desiccate at +4°C
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