Catalog Number: 3259
Chemical Name: (+)-2'-Deoxy-2',2'-difluorocytidine hydrochloride
Biological Activity
Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo.
Technical Data
  • M.Wt:
    299.66
  • Formula:
    C9H11F2N3O4.HCl
  • Solubility:
    Soluble to 100 mM in water and to 20 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    122111-03-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evaluation of the antitumor activity of Gemcitabine (2',2'-Difluoro-2'-deoxycytidine).
    Hertel et al.
    Cancer Res., 1990;50:4417
  2. Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism.
    Heinemann et al.
    Semin.Oncol., 1995;22:11
  3. Preclinical characteristics of gemcitabine.
    Plunkett et al.
    Anticancer Drugs, 1995;6:7
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Gemcitabine hydrochloride include:

8 Citations: Showing 1 - 8
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  1. An automated fitting procedure and software for dose-response curves with multiphasic features.
    Authors: Veroli Et al.
    Mol Cancer Ther 2015;5:14701
  2. DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.
    Authors: Dolman Et al.
    PLoS One 2015;10:e0145744
  3. Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells.
    Authors: Okita Et al.
    PLoS One 2015;10:e0139809
  4. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715.
    Authors: Slee Et al.
    Mol Cancer Ther 2014;13:307
  5. BRCA2 and RAD51 promote double-strand break formation and cell death in response to gemcitabine.
    Authors: Jones Et al.
    PLoS One 2014;13:2412
  6. Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo.
    Authors: Bapiro Et al.
    Br J Cancer 2014;111:318
  7. Characterization of permeability, stability and anti-HIV-1 activity of decitabine and gemcitabine divalerate prodrugs.
    Authors: Clouser Et al.
    Antivir Chem Chemother 2013;23:223
  8. Plk1 phosphorylation of orc2 and hbo1 contributes to gemcitabine resistance in pancreatic cancer.
    Authors: Song Et al.
    Mol Cancer Ther 2013;12:58

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