Catalog Number: 3259
Chemical Name: (+)-2'-Deoxy-2',2'-difluorocytidine hydrochloride
Biological Activity
Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evaluation of the antitumor activity of Gemcitabine (2',2'-Difluoro-2'-deoxycytidine).
    Hertel et al.
    Cancer Res., 1990;50:4417
  2. Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism.
    Heinemann et al.
    Semin.Oncol., 1995;22:11
  3. Preclinical characteristics of gemcitabine.
    Plunkett et al.
    Anticancer Drugs, 1995;6:7
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