Catalog Number: 1743
Alternate Names: Bay 11-7083
Chemical Name: (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
Biological Activity
Irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation (IC50 ~ 10 μM); leads to decreased NF-κB and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo.
Technical Data
  • M.Wt:
    249.33
  • Formula:
    C13H15NO2S
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    196309-76-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism.
    Hu et al.
    Cancer Res., 2001;61:6290
  2. Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis.
    Scaife et al.
    Cancer Res., 2002;62:6870
  3. Novel inhibitors of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo.
    Pierce et al.
    J.Biol.Chem., 1997;272:21096
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Bay 11-7085 include:

3 Citations: Showing 1 - 3
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  1. Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases.
    Authors: Clark Et al.
    PLoS One 2015;10:e0120075
  2. Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3.
    Authors: Przybyla Et al.
    Stem Cells 2013;31:1097
  3. Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis.
    Authors: Hussain Et al.
    PLoS One 2012;7:e39945

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