Chemical Name: (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
Biological ActivityBay 11-7085 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation (IC50 ~ 10 μM); leads to decreased NF-κB and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism.
Hu et al.
Cancer Res., 2001;61:6290
Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis.
Scaife et al.
Cancer Res., 2002;62:6870
Novel inhibitors of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo.
Pierce et al.
Citations for Bay 11-7085
The citations listed below are publications that use Tocris products. Selected citations for Bay 11-7085 include:
6 Citations: Showing 1 - 6
Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders.
Authors: Liang Et al.
J Allergy Clin Immunol 2017;139:1217
Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model.
Authors: Kwon Et al.
J Clin Invest 2016;126:2626
Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases.
Authors: Clark Et al.
PLoS One 2015;10:e0120075
Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells.
Authors: Kwon Et al.
Nat Commun 2014;5:4416
Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3.
Authors: Przybyla Et al.
Stem Cells 2013;31:1097
Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis.
Authors: Hussain Et al.
PLoS One 2012;7:e39945
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