Bay 11-7085

Key Product Details

Product Description

Bay 11-7085 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation (IC₅₀ ~ 10 μM); leads to decreased NF-κB and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo.

Product Specifications for Bay 11-7085

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Bay 11-7085

The following data is based on the product molecular weight 249.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.01 mL	20.05 mL	40.11 mL
5 mM	0.80 mL	4.01 mL	8.02 mL
10 mM	0.40 mL	2.01 mL	4.01 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 34 publications citing the usage of this product.

• Pierce Novel inhibitors of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 1997 PMID: 9261113
• Scaife Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer Res. 2002 PMID: 12460901
• Hu An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism. Cancer Res. 2001 PMID: 11507084

Product Documents for Bay 11-7085