Irreversible inhibitor of TNF-α
~ 10 μ
M); leads to decreased NF-κ
B and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo
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An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism.
Hu et al.
Cancer Res., 2001;61:6290
Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis.
Scaife et al.
Cancer Res., 2002;62:6870
Novel inhibitors of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo.
Pierce et al.
The citations listed below are publications that use Tocris products. Selected citations for Bay 11-7085 include:
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