Bay 11-7085

  ( 4 citations )    
Product Datasheet
Catalog Number:1743
Alternate Names:Bay 11-7083
Chemical Name:(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
Product Details
Citations (4)
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Reviews
Biological Activity
Irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation (IC50 ~ 10 μM); leads to decreased NF-κB and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo.
Technical Data
  • M.Wt:
    249.33
  • Formula:
    C13H15NO2S
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    196309-76-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Bay 11-7085 include:

4 Citations: Showing 1 - 4
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  1. Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases.
    Authors: Clark Et al.
    PLoS One  2015;10:e0120075
  2. Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells.
    Authors: Kwon Et al.
    Nat Commun  2014;5:4416
  3. Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3.
    Authors: Przybyla Et al.
    Stem Cells  2013;31:1097
  4. Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis.
    Authors: Hussain Et al.
    PLoS One  2012;7:e39945

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