Chemical Name: 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide
Biological ActivityOrally effective vanilloid receptor 1 (TRPV1 receptor) antagonist. Inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC50 values are 6.0 and 35 nM respectively). Displays analgesic properties in rat models of inflammatory and neuropathic pain. CNS penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. In vivo characterization in rat models of inflamma
Pomonis et al.
N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. In vitro characterization and pharmacokinetic proper
Valenzano et al.
Citation for BCTC
The citations listed below are publications that use Tocris products. Selected citations for BCTC include:
1 Citation: Showing 1 - 1
Elevated expression of transient receptor potential vanilloid type 1 in dorsal root ganglia of rats with endometriosis.
Authors: Lian Et al.
Mol Med Rep 2017;16:1920
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