Benidipine hydrochloride
Chemical Name: (4R)-rel-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester hydrochloride
Purity: ≥99%
Biological Activity
Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo. Inhibits L-, N- and T-type Ca2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel long-acting calcium channel blocker.
Yao et al.
J.Pharmacol.Sci., 2006;100:243 -
The L-, N-, T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family.
Kosaka et al.
Eur.J.Pharmacol., 2010;635:49
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Citation for Benidipine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Benidipine hydrochloride include:
1 Citation: Showing 1 - 1
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Toxoplasma-Induced Hypermigration of Primary Cortical Microglia Implicates GABAergic Signaling.
Authors: Bhandage Et al.
Front Cell Infect Microbiol 2019;9:73
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