BHQ

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1236/100
BHQ | CAS No. 88-58-4 | Ca2+-ATPase Inhibitors
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Description: Inhibitor of SERCA ATPase

Chemical Name: 1,4-Dihydroxy-2,5-di-tert-butylbenzene

Product Details
Citations (3)
Reviews (1)

Biological Activity

A selective inhibitor of endoplasmic reticulum Ca2+-ATPase.

Technical Data

M.Wt:
222.33
Formula:
C14H22O2
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
88-58-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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BHQ depletes ER Ca2+ store in HEK cells leading to STIM1-Orai1 clustering for store-operated Ca2+ entry.
By Niroj Shrestha on 10/27/2018
Application: Species: Human

ER resident protein, STIM1 and PM resident Orai1 channel were expressed with YFP and CFP fluorescent tags respectively in HEK293 cells and imaged using TIRF microscopy. Basal STIM1 and Orai1 (left) co-clusters to form punctae at PM-ER junctions upon ER store depletion (right) by BHQ (30 µM), leading to store-operated Ca2+ entry through Orai1.


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