Chemical Name: 1,4-Dihydroxy-2,5-di-tert-butylbenzene
Biological ActivityA selective inhibitor of endoplasmic reticulum Ca2+-ATPase.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Effects of three sarcoplasmic/endoplasmic Ca++ pump inhibitors on release channels and intracellular stores.
Dettbarn and Palade
Blockade of the inward rectifier potassium current by the Ca2+-ATPase inhibitor 2',5'-di(tert-butyl)-1,4-benzohydroquinone (BHQ).
Hassessian et al.
2,5-Di-t-butyl-1,4 benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta.
Fusi et al.
Mechanism of rise and decay of 2,5-di-tert-butylhydroquinone-induced Ca2+ signals in Madin Darby canine kidney cells.
Jan et al.
Citations for BHQ
The citations listed below are publications that use Tocris products. Selected citations for BHQ include:
3 Citations: Showing 1 - 3
Pharmacological correction of gating defects in the voltage-gated Ca(v)2.1 Ca2+ channel due to a familial hemiplegic migraine mutation.
Authors: Inagaki Et al.
Disturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells.
Authors: Dai Et al.
J Biol Chem 2012;287:14586
Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria.
Authors: Zhdanov Et al.
Cell Mol Life Sci 2011;68:903
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ER resident protein, STIM1 and PM resident Orai1 channel were expressed with YFP and CFP fluorescent tags respectively in HEK293 cells and imaged using TIRF microscopy. Basal STIM1 and Orai1 (left) co-clusters to form punctae at PM-ER junctions upon ER store depletion (right) by BHQ (30 µM), leading to store-operated Ca2+ entry through Orai1.