Catalog Number: 1236
Chemical Name: 1,4-Dihydroxy-2,5-di-tert-butylbenzene
Biological Activity
A selective inhibitor of endoplasmic reticulum Ca2+-ATPase.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 2,5-Di-t-butyl-1,4 benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta.
    Fusi et al.
    Eur.J.Pharmacol., 1999;366:181
  2. Mechanism of rise and decay of 2,5-di-tert-butylhydroquinone-induced Ca2+ signals in Madin Darby canine kidney cells.
    Jan et al.
    Eur.J.Pharmacol., 1999;365:111
  3. Blockade of the inward rectifier potassium current by the Ca2+-ATPase inhibitor 2',5'-di(tert-butyl)-1,4-benzohydroquinone (BHQ).
    Hassessian et al.
    Br.J.Pharmacol., 1994;112:1118
  4. Effects of three sarcoplasmic/endoplasmic Ca++ pump inhibitors on release channels and intracellular stores.
    Dettbarn and Palade
    J.Pharmacol.Exp.Ther., 1999;285:739

The citations listed below are publications that use Tocris products. Selected citations for BHQ include:

3 Citations: Showing 1 - 3
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  1. Pharmacological correction of gating defects in the voltage-gated Ca(v)2.1 Ca2+ channel due to a familial hemiplegic migraine mutation.
    Authors: Inagaki Et al.
    Neuron 2014;81:91
  2. Disturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells.
    Authors: Dai Et al.
    J Biol Chem 2012;287:14586
  3. Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria.
    Authors: Zhdanov Et al.
    Cell Mol Life Sci 2011;68:903

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