Potent and selective CGRP receptor antagonist (IC50
values are 0.03 and 6.4 nM for human and rat CGRP receptors respectively). Displays high affinity for human CGRP receptors (Ki
= 14.4 pM); exhibits no significant affinity for 75 other receptors.
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Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist.
Doods et al.
Development of human calcitonin gene-related peptide (CGRP) receptor antagonists. 1. Potent and selective small molecule CGRP antagonists. 1-[N2-[3,5-Dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1- piperidinyl
Rudolf et al.
The citations listed below are publications that use Tocris products. Selected citations for BIBN 4096 include:
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