Catalog Number: 3389
Alternate Names: Casodex, ICI 176,334
Chemical Name: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
Biological Activity
Orally active non-steroidal androgen receptor antagonist (IC50 = 190 nM). Displays peripheral selectivity and does not effect serum levels of LH and testosterone. Exhibits potent anticancer activity in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes only under agreement from AstraZeneca
Background References
  1. ICI 176,334: a novel non-steroidal, peripherally selective antiandrogen.
    Furr et al.
    J.Endocrinol., 1987;113:R7
  2. Nonsteroidal antiandrogens. Synthesis and structure-activity relationships of 3-substituted derivatives of 2-hydroxypropionanilides.
    Tucker et al.
    J.Med.Chem., 1988;31:954
  3. The preclinical development of bicalutamide: pharmacodynamics and mechanism of action.
    Furr and Tucker
    Urology, 1996;47:13

The citations listed below are publications that use Tocris products. Selected citations for Bicalutamide include:

3 Citations: Showing 1 - 3
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  1. TLR3 engagement induces IRF-3-dependent apoptosis in androgen-sensitive prostate cancer cells and inhibits tumour growth in vivo.
    Authors: Gambara Et al.
    J Cell Mol Med 2015;19:327
  2. Preclinical Development of ONC1-13B, Novel Antiandrogen for Prostate Cancer Treatment.
    Authors: Ivachtchenko Et al.
    PLoS One 2014;5:133
  3. Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer.
    Authors: Ishizaki Et al.
    Sci Rep 2013;3:1528

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