Chemical Name: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
Biological ActivityBicalutamide is an orally active non-steroidal androgen receptor antagonist (IC50 = 190 nM). Displays peripheral selectivity and does not effect serum levels of LH and testosterone. Exhibits potent anticancer activity in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
ICI 176,334: a novel non-steroidal, peripherally selective antiandrogen.
Furr et al.
Nonsteroidal antiandrogens. Synthesis and structure-activity relationships of 3-substituted derivatives of 2-hydroxypropionanilides.
Tucker et al.
The preclinical development of bicalutamide: pharmacodynamics and mechanism of action.
Furr and Tucker
Citations for Bicalutamide
The citations listed below are publications that use Tocris products. Selected citations for Bicalutamide include:
4 Citations: Showing 1 - 4
The Androgen Receptor Regulates PPARγ Expression and Activity in Human Prostate Cancer Cells.
Authors: Olokpa Et al.
J Cell Physiol 2016;231:2664
TLR3 engagement induces IRF-3-dependent apoptosis in androgen-sensitive prostate cancer cells and inhibits tumour growth in vivo.
Authors: Gambara Et al.
J Cell Mol Med 2015;19:327
Preclinical Development of ONC1-13B, Novel Antiandrogen for Prostate Cancer Treatment.
Authors: Ivachtchenko Et al.
PLoS One 2014;5:133
Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer.
Authors: Ishizaki Et al.
Sci Rep 2013;3:1528
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in vitro culture with c4-2 cells to induce AR reduction