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Bicalutamide

Catalog #: 3389
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3389/10
3389/50
Bicalutamide | CAS No. 90357-06-5 | Androgen Receptor Antagonists
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Description: Non-steroidal androgen receptor antagonist
Alternative Names: Casodex, ICI 176,334

Chemical Name: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide

Purity: ≥99%

Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Bicalutamide is an orally active non-steroidal androgen receptor antagonist (IC50 = 190 nM). Displays peripheral selectivity and does not effect serum levels of LH and testosterone. Exhibits potent anticancer activity in vivo.

Technical Data

M.Wt:
430.37
Formula:
C18H14F4N2O4S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
90357-06-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes only under agreement from AstraZeneca

Product Datasheets

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Reconstitution Calculator

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Citations for Bicalutamide

The citations listed below are publications that use Tocris products. Selected citations for Bicalutamide include:

4 Citations: Showing 1 - 4

  1. The Androgen Receptor Regulates PPARγ Expression and Activity in Human Prostate Cancer Cells.
    Authors: Olokpa Et al.
    J Cell Physiol  2016;231:2664
  2. TLR3 engagement induces IRF-3-dependent apoptosis in androgen-sensitive prostate cancer cells and inhibits tumour growth in vivo.
    Authors: Gambara Et al.
    J Cell Mol Med  2015;19:327
  3. Preclinical Development of ONC1-13B, Novel Antiandrogen for Prostate Cancer Treatment.
    Authors: Ivachtchenko Et al.
    PLoS One  2014;5:133
  4. Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer.
    Authors: Ishizaki Et al.
    Sci Rep  2013;3:1528

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VersaClone cDNA Plasmids

Human Androgen R/NR3C4 (NP_000035) VersaClone cDNA

RDC1285

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