BIO 5192

  ( 1 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:5051
Chemical Name:(2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
Highly selective and potent inhibitor of integrin α4β1 (Very Late Antigen-4; VLA-4) (Kd < 10 pM). Selectively binds α4β1 over a range of other integrins (IC50 values are 1.8, 138, 1053, > 500 and > 10,000 nM for α4β1, α9β1, α2β1, α4β7 and αIIbβ3, respectively). Induces a 30-fold increase in mobilization of murine hematopoietic stem and progenitor cells; displays a 3-fold additive effect with AMD 3100 (Cat. No. 3299). Decreases oxidative damage and improves neurological function following spinal cord injury in rats.
Technical Data
  • M.Wt:
    817.78
  • Formula:
    C38H46Cl2N6O8S
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    327613-57-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BIO 5192 include:

1 Citations: Showing 1 - 1

  1. Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatorymacrophages in cell-to-cell contact-independent and dependent manners under hypoxic culture.
    Authors: Takizawa
    Exp Cell Res  2017;358(2):441

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Average Rating: 4.5 (Based on 2 reviews)

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We have 2 reviews tested in 2 species: Human, Mouse.

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Images Ratings Applications Species Reviewed By Date Details
  Excellent
  Human Martin Bush 05/10/2018
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Summary

Species Human
 In Vivo alpha4 blockade 5051 Array 5051
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Very Good
  Mouse Anonymous 12/22/2017
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Image Details
 In Vivo alpha4 blockade 5051
: In Vivo alpha4 blockade [5051].

Summary

Species Mouse

Other Experimental Details

Other Experimental Details Reconstituted in DMSO. Diluted for use in PBS. Clinical saline caused precipitation.

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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