BIO 5192

Catalog # Availability Size / Price Qty
BIO 5192 | CAS No. 327613-57-0 | Integrin Receptor Inhibitors
1 Image
Description: Highly potent and selective inhibitor of integrin α4β1 (VLA-4)

Chemical Name: (2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products
Reviews (2)

Biological Activity

BIO 5192 is a highly selective and potent inhibitor of integrin α4β1 (Very Late Antigen-4; VLA-4) (Kd < 10 pM). Selectively binds α4β1 over a range of other integrins (IC50 values are 1.8, 138, 1053, > 500 and > 10,000 nM for α4β1, α9β1, α2β1, α4β7 and αIIbβ3, respectively). Induces a 30-fold increase in mobilization of murine hematopoietic stem and progenitor cells; displays a 3-fold additive effect with AMD 3100 (Cat. No. 3299). Decreases oxidative damage and improves neurological function following spinal cord injury in rats.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for BIO 5192

The citations listed below are publications that use Tocris products. Selected citations for BIO 5192 include:

1 Citation: Showing 1 - 1


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for BIO 5192

Average Rating: 4.5 (Based on 2 Reviews)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used BIO 5192?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

a4b1 conformation stabilizer
By Martin Bush on 05/10/2018
Application: Species: Human

We used this small molecule to lock a4b1 in an open conformation for EM imaging. It worked very nicely.

In Vivo alpha4 blockade
By Anonymous on 12/22/2017
Application: Species: Mouse

BIO5192 was administered 10mg/kg daily.

Reconstituted in DMSO. Diluted for use in PBS. Clinical saline caused precipitation.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.