AMD 3100 octahydrochloride

  ( 13 citations )    
Product Datasheet
Catalog Number:3299
Alternate Names:JM 3100, Plerixafor
Chemical Name:1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride
Product Details
Citations (13)
Supplemental Products
Reviews
Biological Activity
Highly selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 μM for CXCR4 and all other chemokine receptors respectively). Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo. Attenuates cocaine place preference and locomotor stimulation in rats. Attenuates microglial activation neurological function after ischemic stroke in mice.
Technical Data
  • M.Wt:
    794.48
  • Formula:
    C28H54N8.8HCl
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    155148-31-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for AMD 3100 octahydrochloride include:

13 Citations: Showing 1 - 10
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  1. Anti-fibrotic effects of CXCR4-targeting i-body AD-114 in preclinical models of pulmonary fibrosis.
    Authors: Griffiths
    Sci Rep  2018;8(1):3212
  2. CXCR4-expressing Mist1 + progenitors in the gastric antrum contribute to gastric cancer development.
    Authors: Sakitani
    Oncotarget  2017;8(67):111012
  3. Modeling selective elimination of quiescent cancer cells from bone marrow.
    Authors: Cavnar Et al.
    Cell  2015;17:625
  4. CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis.
    Authors: Chu Et al.
    Neoplasia  2015;10:e0133616
  5. Macrophage Migration Inhibitory Factor Mediates PAR-Induced Bladder Pain.
    Authors: Kouzoukas Et al.
    PLoS One  2015;10:e0127628
  6. CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit+ cells in rats.
    Authors: Farkas Et al.
    PLoS One  2014;9:e89810
  7. Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination.
    Authors: Mycko Et al.
    J Neurosci  2014;34:8646
  8. CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.
    Authors: Beck Et al.
    J Exp Med  2014;211:2567
  9. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma.
    Authors: Zhang Et al.
    Neoplasia  2013;154:1060
  10. Rhythmic modulation of the hematopoietic niche through neutrophil clearance.
    Authors: Casanova-Acebes Et al.
    Cell  2013;153:1025
  11. Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists.
    Authors: Chigaev Et al.
    J Biol Chem  2011;286:5455
  12. Endothelial progenitor cells contribute to the vascularization of endometriotic lesions.
    Authors: Laschke Et al.
    Development  2011;178:442
  13. Noninvasive imaging reveals inhibition of ovarian cancer by targeting CXCL12-CXCR4.
    Authors: Ray Et al.
    Am J Pathol  2011;13:1152
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