AMD 3100 octahydrochloride

  ( 13 citations )    
Product Datasheet
Catalog Number:3299
Alternate Names:JM 3100, Plerixafor
Chemical Name:1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride
Product Details
Citations (13)
Supplemental Products
Biological Activity
Highly selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 μM for CXCR4 and all other chemokine receptors respectively). Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo. Attenuates cocaine place preference and locomotor stimulation in rats. Attenuates microglial activation neurological function after ischemic stroke in mice.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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The citations listed below are publications that use Tocris products. Selected citations for AMD 3100 octahydrochloride include:

13 Citations: Showing 1 - 10
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  1. Anti-fibrotic effects of CXCR4-targeting i-body AD-114 in preclinical models of pulmonary fibrosis.
    Authors: Griffiths
    Sci Rep  2018;8(1):3212
  2. CXCR4-expressing Mist1 + progenitors in the gastric antrum contribute to gastric cancer development.
    Authors: Sakitani
    Oncotarget  2017;8(67):111012
  3. Modeling selective elimination of quiescent cancer cells from bone marrow.
    Authors: Cavnar Et al.
    Cell  2015;17:625
  4. CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis.
    Authors: Chu Et al.
    Neoplasia  2015;10:e0133616
  5. Macrophage Migration Inhibitory Factor Mediates PAR-Induced Bladder Pain.
    Authors: Kouzoukas Et al.
    PLoS One  2015;10:e0127628
  6. CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit+ cells in rats.
    Authors: Farkas Et al.
    PLoS One  2014;9:e89810
  7. Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination.
    Authors: Mycko Et al.
    J Neurosci  2014;34:8646
  8. CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.
    Authors: Beck Et al.
    J Exp Med  2014;211:2567
  9. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma.
    Authors: Zhang Et al.
    Neoplasia  2013;154:1060
  10. Rhythmic modulation of the hematopoietic niche through neutrophil clearance.
    Authors: Casanova-Acebes Et al.
    Cell  2013;153:1025
  11. Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists.
    Authors: Chigaev Et al.
    J Biol Chem  2011;286:5455
  12. Endothelial progenitor cells contribute to the vascularization of endometriotic lesions.
    Authors: Laschke Et al.
    Development  2011;178:442
  13. Noninvasive imaging reveals inhibition of ovarian cancer by targeting CXCL12-CXCR4.
    Authors: Ray Et al.
    Am J Pathol  2011;13:1152
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