AMD 3100 octahydrochloride

Key Product Details

Product Description

AMD 3100 octahydrochloride is a highly selective CXCR4 chemokine receptor antagonist (IC₅₀ values are 0.02 - 0.13 and > 25 μM for CXCR4 and most other chemokine receptors, respectively). Also CXCR7 allosteric agonist. Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC₅₀ = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo. Attenuates cocaine place preference and locomotor stimulation in rats. Attenuates microglial activation neurological function after ischemic stroke in mice. Inhibits tumor cell migration and proliferation in vitro and in vivo in a range of cancers.

Product Specifications for AMD 3100 octahydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AMD 3100 octahydrochloride

The following data is based on the product molecular weight 794.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.26 mL	6.29 mL	12.59 mL
5 mM	0.25 mL	1.26 mL	2.52 mL
10 mM	0.13 mL	0.63 mL	1.26 mL
50 mM	0.03 mL	0.13 mL	0.25 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 34 publications citing the usage of this product.

• Kalatskaya MD3100 Is a CXCR7 ligand with allosteric agonist properties. Mol.Pharmacol, 2009 PMID: 19255243
• Wu A novel CXCR4 antagonist CX549 induces neuroprotection in stroke brain. Cell.Transplant. 2017 PMID:  27938478
• Burger and Peled CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers. Leukemia 2009 PMID: 18987663
• Kim Chemokines and cocaine: CXCR4 receptor antagonist AMD3100 attenuates cocaine place preference and locomotor stimulation in rats. Brain Behav.Immun. 2017 PMID: 27575003
• Paganessi Effective mobilization of hematopoietic progenitor cells in G-CSF mobilization defective CD26-/- mice through AMD3100-induced disruption of the CXCL12-CXCR4 axis. Exp.Hematol. 2011 PMID: 21168468
• Hatse Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4. FEBS Letts. 2002 PMID: 12220670
• Hogaboam The therapeutic potential in targeting CCR5 and CXCR4 receptors in infectious and allergic pulmonary disease. Pharmacol.Ther. 2005 PMID: 16009428
• Bridger Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibits HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker. J.Med.Chem. 1995 PMID: 7830280

Product Documents for AMD 3100 octahydrochloride