AMD 3100 octahydrochloride

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AMD 3100 octahydrochloride | CAS No. 155148-31-5 | Chemokine Receptor Antagonists
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Description: Highly selective CXCR4 antagonist
Alternative Names: JM 3100, Plerixafor

Chemical Name: 1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride

Product Details
Citations (16)
Supplemental Products

Biological Activity

AMD 3100 octahydrochloride is a highly selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 μM for CXCR4 and most other chemokine receptors, respectively). Also CXCR7 allosteric agonist. Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo. Attenuates cocaine place preference and locomotor stimulation in rats. Attenuates microglial activation neurological function after ischemic stroke in mice. Inhibits tumor cell migration and proliferation in vitro and in vivo in a range of cancers.

Technical Data

Soluble to 100 mM in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for AMD 3100 octahydrochloride

The citations listed below are publications that use Tocris products. Selected citations for AMD 3100 octahydrochloride include:

16 Citations: Showing 1 - 10

  1. Oral Pathobiont Activates Anti-Apoptotic Pathway, Promoting both Immune Suppression and Oncogenic Cell Proliferation.
    Authors: Arjunan Et al.
    Sci Rep  2018;8:16607
  2. Anti-fibrotic effects of CXCR4-targeting i-body AD-114 in preclinical models of pulmonary fibrosis.
    Authors: Griffiths
    Sci Rep  2018;8(1):3212
  3. Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues.
    Authors: He Et al.
    Immunity  2018;49:1175
  4. CXCR4-expressing Mist1 + progenitors in the gastric antrum contribute to gastric cancer development.
    Authors: Sakitani
    Oncotarget  2017;8(67):111012
  5. Agarose Spot as a Comparative Method for in situ Analysis of Simultaneous Chemotactic Responses to Multiple Chemokines.
    Authors: Ahmed Et al.
    Sci Rep  2017;7:1075
  6. Modeling selective elimination of quiescent cancer cells from bone marrow.
    Authors: Cavnar Et al.
    Cell  2015;17:625
  7. CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis.
    Authors: Chu Et al.
    Neoplasia  2015;10:e0133616
  8. Macrophage Migration Inhibitory Factor Mediates PAR-Induced Bladder Pain.
    Authors: Kouzoukas Et al.
    PLoS One  2015;10:e0127628
  9. CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit+ cells in rats.
    Authors: Farkas Et al.
    PLoS One  2014;9:e89810
  10. Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination.
    Authors: Mycko Et al.
    J Neurosci  2014;34:8646


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