BMS 191011

Catalog # Availability Size / Price Qty
2665/10
2665/50
BMS 191011 | CAS No. 202821-81-6 | Ca2+-Activated Potassium Channel Activators
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Description: Potent BKCa (KCa1.1) channel opener

Chemical Name: 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one

Purity: ≥99%

Product Details
Citations (3)
Reviews (1)

Biological Activity

Potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).

Technical Data

M.Wt:
370.71
Formula:
C16H10ClF3N2O3
Solubility:
Soluble to 100 mM in DMSO and to 15 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
202821-81-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca2+-activated potassium (Maki-K) channels, identification, solubility, and SAR.
    Romine et al.
    J.Med.Chem., 2007;50:528
  2. Synthesis of water-soluble prodrugs of BMS-191011: a Maxi-K channel opener targeted for post-stroke neuroprotection.
    Hewawasam et al.
    Bioorg.Med.Chem.Letts., 2003;13:1695

Product Datasheets

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Citations for BMS 191011

The citations listed below are publications that use Tocris products. Selected citations for BMS 191011 include:

3 Citations: Showing 1 - 3

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BK channel activator with great research potential
By Anonymous on 10/29/2018
Application: Species: Human

The product was used to study BK channels expressed in brain. It shows moderate channel opening, works well in expperimental conditions and is stable.


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