Chemical Name: 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one
Biological ActivityBMS 191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca2+-activated potassium (Maki-K) channels, identification, solubility, and SAR.
Romine et al.
Synthesis of water-soluble prodrugs of BMS-191011: a Maxi-K channel opener targeted for post-stroke neuroprotection.
Hewawasam et al.
Citations for BMS 191011
The citations listed below are publications that use Tocris products. Selected citations for BMS 191011 include:
3 Citations: Showing 1 - 3
Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid.
Authors: Martin Et al.
Mucosal Immunol 2014;7:101
Maternal nutrient restriction during pregnancy impairs an endothelium-derived hyperpolarizing factor-like pathway in sheep fetal coronary arteries.
Authors: Shukla Et al.
Am J Physiol Heart Circ Physiol 2014;307:H134
Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors.
Authors: Eroglu Et al.
Int J Neuropsychopharmacol 2012;287:15886
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Reviews for BMS 191011
Average Rating: 5 (Based on 1 Review)
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The product was used to study BK channels expressed in brain. It shows moderate channel opening, works well in expperimental conditions and is stable.