Catalog Number: 2665
Chemical Name: 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one
Biological Activity
Potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).
Technical Data
  • M.Wt:
    370.71
  • Formula:
    C16H10ClF3N2O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 15 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    202821-81-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca2+-activated potassium (Maki-K) channels, identification, solubility, and SAR.
    Romine et al.
    J.Med.Chem., 2007;50:528
  2. Synthesis of water-soluble prodrugs of BMS-191011: a Maxi-K channel opener targeted for post-stroke neuroprotection.
    Hewawasam et al.
    Bioorg.Med.Chem.Letts., 2003;13:1695
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BMS 191011 include:

2 Citations: Showing 1 - 2
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  1. Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid.
    Authors: Martin Et al.
    Mucosal Immunol 2014;7:101
  2. Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors.
    Authors: Eroglu Et al.
    Int J Neuropsychopharmacol 2012;287:15886

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