BMS 345541

Catalog # Availability Size / Price Qty
4806/10
4806/50
BMS 345541 | CAS No. 547757-23-3 | IkB Kinase Inhibitors
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Description: Selective allosteric inhibitor of IKK; anti-inflammatory

Chemical Name: N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

BMS 345541 is a selective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 μM for IKKβ and IKKα respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.

Technical Data

M.Wt:
291.78
Formula:
C14H17N5.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
547757-23-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for BMS 345541

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