Selective inhibitor of Ca2+
-calmodulin-dependent protein phosphatase (calcineurin) (IC50
~ 10 μ
M). Does not inhibit PP1, PP2A or CaM kinase II (IC50
> 100 mM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification of an autoinhibitory domain in calcineurin.
Hashimoto et al.
Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin.
Perrino et al.
The role of the autoinhibitory domain in differential metal ion activation of calmodulin-stimulated phosphatase.
Yokoyama and Wang
FEBS Lett., 1994;337:128
The citations listed below are publications that use Tocris products. Selected citations for Calcineurin Autoinhibitory Peptide include:
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