Calcineurin Autoinhibitory Peptide
Biological ActivityCalcineurin Autoinhibitory Peptide is a selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of an autoinhibitory domain in calcineurin.
Hashimoto et al.
Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin.
Perrino et al.
The role of the autoinhibitory domain in differential metal ion activation of calmodulin-stimulated phosphatase.
Yokoyama and Wang
FEBS Lett., 1994;337:128
Citations for Calcineurin Autoinhibitory Peptide
The citations listed below are publications that use Tocris products. Selected citations for Calcineurin Autoinhibitory Peptide include:
3 Citations: Showing 1 - 3
Cyclosporin A attenuating MOR tolerance through inhibiting NO/ERK signaling pathway in human glioblastoma cell line: the involvement of calcineurin.
Authors: Rashki Et al.
EXCLI J 2019;17:1137
Tonic 5nM DA stabilizes neuronal output by enabling bidirectional activity-dependent regulation of the hyperpolarization activated current via PKA and calcineurin.
Authors: Krenz Et al.
PLoS One 2015;10:e0117965
Endocytosis and recycling of AMPA receptors lacking GluR2/3.
Authors: Biou Et al.
J Pharmacol Exp Ther 2008;105:1038
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