Catalog Number: 1891
Alternate Names: Autoinhibitory peptide 457-482
Biological Activity
Selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM).
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of an autoinhibitory domain in calcineurin.
    Hashimoto et al.
    J.Biol.Chem., 1990;265:1924
  2. Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin.
    Perrino et al.
    J.Biol.Chem., 1995;270:340
  3. The role of the autoinhibitory domain in differential metal ion activation of calmodulin-stimulated phosphatase.
    Yokoyama and Wang
    FEBS Lett., 1994;337:128

The citations listed below are publications that use Tocris products. Selected citations for Calcineurin Autoinhibitory Peptide include:

2 Citations: Showing 1 - 2
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  1. Tonic 5nM DA stabilizes neuronal output by enabling bidirectional activity-dependent regulation of the hyperpolarization activated current via PKA and calcineurin.
    Authors: Krenz Et al.
    PLoS One 2015;10:e0117965
  2. Endocytosis and recycling of AMPA receptors lacking GluR2/3.
    Authors: Biou Et al.
    J Pharmacol Exp Ther 2008;105:1038

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