Cannabinol

Key Product Details

Product Description

Cannabinol is a CB₂ and CB₁ receptor agonist (K_i values are 126 and 211 nM respectively). Inhibits adenylyl cyclase (EC₅₀ values are 120 and 261 nM for CB₁ and CB₂ receptors respectively) and suppresses immune cell function. Major constituent of cannabis; displays little or no psychotropic activity.

Product Specifications for Cannabinol

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Cannabinol

The following data is based on the product molecular weight 310.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.44 mL	32.21 mL	64.43 mL
2.5 mM	1.29 mL	6.44 mL	12.89 mL
5 mM	0.64 mL	3.22 mL	6.44 mL
25 mM	0.13 mL	0.64 mL	1.29 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Herring Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kB elements by cannabinol, a minimally CNS-active cannabinoid. Biochem.Pharmacol. 1998 PMID: 9605425
• Zygmunt Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB₁ and CB₂ cannabinoid receptor-independent mechanism. J.Neurosci. 2002 PMID: 12040079
• Rhee Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylyl cyclase. J.Med.Chem. 1997 PMID: 9379442

Product Documents for Cannabinol