Cannabinol
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Description: Cannabinoid receptor agonist; not psychoactive
Alternative Names: CBN
Chemical Name: 6,6,9-Trimethyl-3-pentyl-6H-benzo[c]chromen-1-ol
Biological Activity
Cannabinol is a CB2 and CB1 receptor agonist (Ki values are 126 and 211 nM respectively). Inhibits adenylyl cyclase (EC50 values are 120 and 261 nM for CB1 and CB2 receptors respectively) and suppresses immune cell function. Major constituent of cannabis; displays little or no psychotropic activity.Technical Data
M.Wt:
310.43
Formula:
C21H26O2
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol
Storage:
Store at -20°C
CAS No:
521-35-7
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylyl cyclase.
Rhee et al.
J.Med.Chem., 1997;40:3228 -
Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kB elements by cannabinol, a minimally CNS-active cannabinoid.
Herring et al.
Biochem.Pharmacol., 1998;55:1013 -
Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism.
Zygmunt et al.
J.Neurosci., 2002;22:4720
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